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The role of chick Ebf genes in the mediolateral patterning of the somites (2019)
Journal Article
EL-Magd, M. A., Elsayed, S. A., El-Shetry, E. S., Abdelfattah-Hassan, A., Saleh, A. A., Allen, S., McGonnell, I. M., & Patel, K. (2019). The role of chick Ebf genes in the mediolateral patterning of the somites. https://doi.org/10.1002/dvg.23339

This study was conducted to check whether the three chick Early B‐cell Factor (Ebf) genes, particularly cEbf1, would be targets for Shh and Bmp signals during somites mediolateral (ML) patterning. Tissue manipulations and gain and loss of function ex... Read More about The role of chick Ebf genes in the mediolateral patterning of the somites.

Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level (2019)
Journal Article
Clark, J. N., Garbout, A., Ferreira, S. A., Javaheri, B., Pitsillides, A. A., Rankin, S. M., Jeffers, J. R. T., & Hansen, U. (2019). Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level. Osteoarthritis and Cartilage, 28, 102-111. https://doi.org/10.1016/j.joca.2019.10.007

High-resolution non-invasive three-dimensional (3D) imaging of chondrocytes in articular cartilage remains elusive. The aim of this study was to explore whether laboratory micro-computed tomography (micro-CT) permits imaging cells within articular ca... Read More about Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level.

Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species (2019)
Journal Article
Proskuryakova, A. A., Kulemzina, A. I., Perelman, P. L., Yudkin, D. V., Lemskaya, N. A., Okhlopkov, I. M., Kirillin, E. V., Farré, M., Larkin, D. M., Roelke-Parker, M. E., O'Brien, S. J., Bush, M., & Graphodatsky, A. S. (2019). Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species. Genes, 10(11), 857. https://doi.org/10.3390/genes10110857

Bovidae, the largest family in Pecora infraorder, are characterized by a striking variability in diploid number of chromosomes between species and among individuals within a species. The bovid X chromosome is also remarkably variable, with several mo... Read More about Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species.

Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells (2019)
Journal Article
Michael, A. E., Thurston, L. M., & Fowkes, R. C. (2019). Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells. Biology, 8(4), 81. https://doi.org/10.3390/biology8040081

The regulation of reproductive function by glucocorticoids occurs at all levels of the hypothalamo-pituitary-gonadal axis. Within the pituitary, glucocorticoids have been shown to directly alter gene expression in gonadotrophs, indicating that these... Read More about Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells.

Dysregulated cell signalling and reduced satellite cell potential in ageing muscle (2019)
Journal Article
Patel, K., Simbi, B. H., Ritvos, O., Vaiyapuri, S., & Dhoot, G. K. (2019). Dysregulated cell signalling and reduced satellite cell potential in ageing muscle. Experimental Cell Research, 385(2), https://doi.org/10.1016/j.yexcr.2019.111685

Aberrant activation of signalling pathways has been postulated to promote age related changes in skeletal muscle. Cell signalling activation requires not only the expression of ligands and receptors but also an appropriate environment that facilitate... Read More about Dysregulated cell signalling and reduced satellite cell potential in ageing muscle.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex (2019)
Journal Article
Yli-Karjanmaa, M., Larsen, K. S., Fenger, C. D., Kellemann Kristensen, L., Martin, N. A., Jensen, P. T., Breton, A., Nathanson, L., Nielsen, P. V., Lund, M. C., Lindeman Carlsen, S., Gramsbergen, J. B., Finsen, B., Stubbe, J., Frich, L. H., Stolp, H. B., Brambilla, R., Anthony, D. C., Meyer, M., & Lambertsen, K. L. (2019). TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex. Brain, Behavior, and Immunity, 82, 279-297. https://doi.org/10.1016/j.bbi.2019.08.195

Ontogenetic scaling of pelvic limb muscles, tendons and locomotor economy in the Ostrich (Struthio camelus) (2019)
Journal Article
Channon, S. B., Young, I. S., Cordner, B., & Swann, N. (2019). Ontogenetic scaling of pelvic limb muscles, tendons and locomotor economy in the Ostrich (Struthio camelus). Journal of Experimental Biology, https://doi.org/10.1242/jeb.182741

In rapidly growing animals there are numerous selective pressures and developmental constraints underpinning the ontogenetic development of muscle-tendon morphology and mechanical properties. Muscle force generating capacity, tendon stiffness, elasti... Read More about Ontogenetic scaling of pelvic limb muscles, tendons and locomotor economy in the Ostrich (Struthio camelus).

Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes (2019)
Journal Article
Attardo, G. M., Abd-Alla, A. M. M., Acosta-Serrano, A., Allen, J. E., Bateta, R., Benoit, J. B., Bourtzis, K., Caers, J., Caljon, G., Christensen, M. B., Farrow, D. W., Friedrich, M., Hua-Van, A., Jennings, E. C., Larkin, D. M., Lawson, D., Lehane, M. J., Lenis, V. P., Lowy-Gallego, E., Macharia, R. W., …Aksoy, S. (2019). Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes. Genome Biology, 20, 187. https://doi.org/10.1186/s13059-019-1768-2

Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate vivip... Read More about Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.

Testing the function of dromaeosaurid (Dinosauria, Theropoda) 'sickle claws' through musculoskeletal modelling and optimization (2019)
Journal Article
Bishop, P. J. (2019). Testing the function of dromaeosaurid (Dinosauria, Theropoda) 'sickle claws' through musculoskeletal modelling and optimization. PeerJ, e7577. https://doi.org/10.7717/peerj.7577

Dromaeosaurids were a clade of bird-like, carnivorous dinosaurs that are well known for their characteristic morphology of pedal digit II, which bore an enlarged, sickle-shaped claw and permitted an extreme range of flexion–extension. Proposed functi... Read More about Testing the function of dromaeosaurid (Dinosauria, Theropoda) 'sickle claws' through musculoskeletal modelling and optimization.

Ground reaction forces of overground galloping in ridden Thoroughbred racehorses (2019)
Journal Article
Self Davies, Z. T., Spence, A. J., & Wilson, A. M. (2019). Ground reaction forces of overground galloping in ridden Thoroughbred racehorses. Journal of Experimental Biology, https://doi.org/10.1242/jeb.204107

The horse has evolved to gallop economically at high speed. Limb force increases with speed but direct measures of limb ground reaction forces (GRFs) at gallop are sparse. This study reports GRFs for multiple limbs, using force plates, across seven T... Read More about Ground reaction forces of overground galloping in ridden Thoroughbred racehorses.

Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One? (2019)
Journal Article
Concordet, D., Gandia, P., Montastruc, J.-L., Bousquet-Mélou, A., Lees, P., Ferran, A. A., & Toutain, P.-L. (2019). Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?. Clinical Pharmacokinetics, 59, 1-5. https://doi.org/10.1007/s40262-019-00812-x

At the request of French Regulatory Authorities, a new formulation of Levothyrox® was licensed in France in 2017, with the objective of avoiding the stability deficiencies of an existing licensed formulation. Before launching the new formulation, an... Read More about Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?.

An integrated chromosome-scale genome assembly of the Masai Giraffe (Giraffa camelopardalis tippelskirchi) (2019)
Journal Article
Farré, M., Qiye, L., Daroli, I., Zhou, Y., Damas, J., Proskuryakova, A. A., Kulemzina, A. I., Chemnick, L. G., Kim, J., Ryder, O. A., Ma, J., Graphodatsky, A. S., Zhang, G., Larkin, D. M., & Lewin, H. A. (2019). An integrated chromosome-scale genome assembly of the Masai Giraffe (Giraffa camelopardalis tippelskirchi). GigaScience, 8(8), https://doi.org/10.1093/gigascience/giz090

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human (2019)
Journal Article
Stolp, H. B., Fleiss, B., Arai, Y., Supramaniam, V., Vontell, R., Birtles, S., Yates, A., Baburamani, A. A., Thornton, C., Rutherford, M., Edwards, A. D., & Gressens, P. (2019). Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human. Frontiers in Physiology, 10(955), https://doi.org/10.3389/fphys.2019.00955

Preterm brain injury, occurring in approximately 30% of infants born

Dchs1-Fat4 regulation of osteogenic differentiation in mouse (2019)
Journal Article
Crespo-Enriquez, I., Hodgson, T., Zakaria, S., Cadoni, E., Shah, M., Allen, S., Al-Krishali, A., Mao, Y., Yiu, A., Villagomez-Olea, G., Petzold, J., Pitsillides, A. A., Irvine, K., & Francis-West, P. (2019). Dchs1-Fat4 regulation of osteogenic differentiation in mouse. Development, 146, https://doi.org/10.1242/dev.176776

In human, mutations of the protocadherins FAT4 and DCHS1 result in Van Maldergem syndrome, which is characterised, in part, by craniofacial abnormalities. Here, we analyse the role of Dchs1-Fat4 signalling during osteoblast differentiation in mouse.... Read More about Dchs1-Fat4 regulation of osteogenic differentiation in mouse.

Inhibition of vascular smooth muscle cell calcification by ATP-analogues (2019)
Journal Article
Patel, J. J., Bourne, L. E., Millán, J. L., Arnett, T. R., MacRae, V. E., Wheeler-Jones, C. P. D., & Orriss, I. R. (2019). Inhibition of vascular smooth muscle cell calcification by ATP-analogues. Purinergic Signalling, 15(3), 315-326. https://doi.org/10.1007/s11302-019-09672-3

Arterial medial calcification (AMC) has been associated with phenotypic changes in vascular smooth muscle cells (VSMCs) that reportedly makes them more osteoblast-like. Previous work has shown that ATP/UTP can inhibit AMC directly via P2 receptors an... Read More about Inhibition of vascular smooth muscle cell calcification by ATP-analogues.

Estimating Overwintering Monarch Butterfly Populations Using Terrestrial LiDAR Scanning (2019)
Journal Article
Hristov, N. I., Nikolaidis, D., Hubel, T. Y., & Allen, L. C. (2019). Estimating Overwintering Monarch Butterfly Populations Using Terrestrial LiDAR Scanning. https://doi.org/10.3389/fevo.2019.00266

Concerns about the state of decline of the North American monarch butterfly (Danaus plexippus) have prompted their consideration for listing under the Endangered Species Act. Data suggest a substantial decline (> 80%) in overwintering numbers for bot... Read More about Estimating Overwintering Monarch Butterfly Populations Using Terrestrial LiDAR Scanning.