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Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows (2019)
Journal Article
Tombacz, K., Peters, L. M., Chang, Y. M., Steele, M., Werling, D., & Gibson, A. J. (2019). Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows. Journal of Dairy Science, 102(10), 9389-9395. https://doi.org/10.3168/jds.2019-16563

In periparturient dairy cows, immune suppression, resulting in decreased neutrophil numbers and function, leads to increased susceptibility to postpartum conditions such as mastitis, retained placenta, and metritis. Administration of polyethylene gly... Read More about Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows.

Energy turnover in mammalian skeletal muscle in contractions mimicking locomotion: effects of stimulus pattern on work, impulse and energetic cost and efficiency (2019)
Journal Article
Curtin, N. A., Woledge, R. C., West, T. G., Goodwin, D., Piercy, R. J., & Wilson, A. M. (2019). Energy turnover in mammalian skeletal muscle in contractions mimicking locomotion: effects of stimulus pattern on work, impulse and energetic cost and efficiency. Journal of Experimental Biology, 222, https://doi.org/10.1242/jeb.203877

Active muscle performs various mechanical functions during locomotion: work output during shortening, work absorption when resisting (but not preventing) lengthening, and impulse (force–time integral) whenever there is active force. The energetic cos... Read More about Energy turnover in mammalian skeletal muscle in contractions mimicking locomotion: effects of stimulus pattern on work, impulse and energetic cost and efficiency.

What is the level of dystrophin expression required for effective therapy of Duchenne muscular dystrophy? (2019)
Journal Article
Wells, D. J. (2019). What is the level of dystrophin expression required for effective therapy of Duchenne muscular dystrophy?. Journal of Muscle Research and Cell Motility, 40(2), 141-150. https://doi.org/10.1007/s10974-019-09535-9

Duchenne muscular dystrophy (DMD) is a fatal X-linked muscle wasting disease. The disease is due to mutations in the DMD gene that encodes for a large intracellular protein called dystrophin. Dystrophin plays a critical role in linking the internal c... Read More about What is the level of dystrophin expression required for effective therapy of Duchenne muscular dystrophy?.

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial (2019)
Journal Article
Sanchis-Mora, S., Chang, Y. M., Abeyesinghe, S. M., Fisher, A., Upton, N., Volk, H. A., & Pelligand, L. (2019). Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. https://doi.org/10.1016/j.tvjl.2019.06.006

Pregabalin is the first-line treatment for neuropathic pain (NeP) in humans. Dogs with Chiari-like malformation and syringomyelia (CM/SM) associated with NeP could benefit from pregabalin. The aim of this study was to evaluate the efficacy of pregaba... Read More about Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial.

Regulation of the bone vascular network is sexually dimorphic (2019)
Journal Article
Goring, A., Sharma, A., Javaheri, B., Smith, R. C., Kanczler, J. M., Boyde, A., Hesse, E., Mahajan, S., Olsen, B. R., Pitsillides, A. A., Schneider, P., Oreffo, R. O., & Clarkin, C. E. (2019). Regulation of the bone vascular network is sexually dimorphic. Journal of Bone and Mineral Research, https://doi.org/10.1002/jbmr.3825

Osteoblast (OB) lineage cells are an important source of vascular endothelial growth factor (VEGF), which is critical for bone growth and repair. During bone development, pubertal differences in males and females exist, but little is known about whet... Read More about Regulation of the bone vascular network is sexually dimorphic.

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses (2019)
Journal Article
Gozalo-Marcilla, M., Rodrigues De Oliveira, A., Werneck Fonseca, M., Possebon, F. S., Pelligand, L., Taylor, P. M., & Luna, S. P. L. (2019). Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses. Equine Veterinary Journal, 51(4), 530-536. https://doi.org/10.1111/evj.13054

Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs (2019)
Journal Article
Pelander, L., Brunchault, V., Buffin-Meyer, B., Klein, J., Breuil, B., Zürbig, P., Magalhães, P., Mullen, W., Elliott, J., Syme, H. M., Schanstra, J. P., Häggström, J., & Ljungvall, I. (2019). Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs. https://doi.org/10.1016/j.tvjl.2019.05.010

Chronic kidney disease (CKD) is clinically important in canine medicine. Current diagnostic tools lack sensitivity for detection of subclinical CKD. The aim of the present study was to evaluate urinary peptidome analysis for diagnosis of CKD in dogs.... Read More about Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs.

Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts (2019)
Journal Article
Patel, J. J., Bourne, L. E., Davies, B. K., Arnett, T. R., MacRae, V. E., Wheeler-Jones, C. P. D., & Orriss, I. R. (2019). Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts. Experimental Cell Research, 380(1), 100-113. https://doi.org/10.1016/j.yexcr.2019.04.020

Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, in the medial layer of the arteries. AMC shares some similarities to skeletal mineralisation and has been associated with the transdifferenti... Read More about Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts.

Physics of Animal Health: On the mechano-biology of hoof growth and form (2019)
Journal Article
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., Atwood, R. C., Rutland, C. S., Menzies-Gow, N. J., Knowles, E., Elliott, J., Harris, P., & Rauch, C. (2019). Physics of Animal Health: On the mechano-biology of hoof growth and form. https://doi.org/10.1098/rsif.2019.0214

Global inequalities in economic access and agriculture productivity imply that a large number of developing countries rely on working equids for transport/agriculture/mining. Therefore, the understanding of hoof conditions/shape variations affecting... Read More about Physics of Animal Health: On the mechano-biology of hoof growth and form.

Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome (2019)
Journal Article
Pittaway, R., Dobromylskyj, M. J., Erles, K., Pittaway, C. E., Suárez-Bonnet, A., Chang, Y. M., & Priestnall, S. L. (2019). Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome. Veterinary Pathology, 56(6), 868-877. https://doi.org/10.1177/0300985819854435

Nonocular melanocytic neoplasia is considered uncommon in cats yet is routinely encountered in diagnostic pathology and recognized to exhibit a wide variation in biological behavior. Accurate prediction of clinical outcomes is challenging with no wid... Read More about Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome.

Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases (2019)
Journal Article
Dunkel, B., Mason, C. J., & Chang, Y. M. (2019). Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.12851

A recent study described increased l‐lactate concentrations in ponies with gastrointestinal disease compared to horses, but blood glucose (BG) concentrations were not considered. The study tested the hypothesis that BG and l‐lactate concentrations ar... Read More about Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases.

Targeting Drp1 and mitochondrial fission for therapeutic immune modulation (2019)
Journal Article
Simula, L., Campanella, M., & Campello, S. (2019). Targeting Drp1 and mitochondrial fission for therapeutic immune modulation. Pharmacological Research, 146, https://doi.org/10.1016/j.phrs.2019.104317

Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to... Read More about Targeting Drp1 and mitochondrial fission for therapeutic immune modulation.

Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens (2019)
Journal Article
Pelligand, L., Lees, P., Sidhu, P. K., & Toutain, P.-L. (2019). Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.01237

An important application of time-kill curve (TKC) assays is determination of the nature of the best PK/PD index (fAUC/MIC or fT% > MIC) and its target value for predicting clinical efficacy in vivo. VetCAST (the veterinary subcommittee of EUCAST) her... Read More about Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens.

Digital dissection of the pelvis and hindlimb of the red-legged running frog, Phlyctimantis maculatus, using Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT) (2019)
Journal Article
Collings, A. J., & Richards, C. T. (2019). Digital dissection of the pelvis and hindlimb of the red-legged running frog, Phlyctimantis maculatus, using Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT). PeerJ, 7, e7003. https://doi.org/10.7717/peerj.7003

The current study applies both traditional and Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT) techniques to reveal the musculoskeletal anatomy of Phlyctimantis maculatus. DICE µCT has emerged as a powerful tool to visualise i... Read More about Digital dissection of the pelvis and hindlimb of the red-legged running frog, Phlyctimantis maculatus, using Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT).

Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart (2019)
Journal Article
Lowe, V., Wisniewski, L., Sayers, J., Evans, I., Frankel, P., Mercader-Huber, N., Zachary, I. C., & Pellet-Many, C. (2019). Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart. Development, 146, https://doi.org/10.1242/dev.174482

Unlike adult mammals, zebrafish can regenerate their heart. A key mechanism for regeneration is the activation of the epicardium, leading to the establishment of a supporting scaffold for new cardiomyocytes, angiogenesis and cytokine secretion. Neuro... Read More about Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart.

Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin (2019)
Journal Article
Jamaludin, N. A., Thurston, L. M., Witek, K. J., Meikle, A., Basatvat, S., Elliott, S., Hunt, S., Andronowska, A., & Fazeli, A. (2019). Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin. Theriogenology, 135, 121-137. https://doi.org/10.1016/j.theriogenology.2019.06.002

Effective communication between the maternal reproductive tract, gametes and the pre-implantation embryo is essential for the successful establishment of pregnancy. Recent studies have recognised extracellular vesicles (EVs) as potent vehicles for in... Read More about Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin.

Post-mortem Characterisation of a Case With an ACTG1 Variant, Agenesis of the Corpus Callosum and Neuronal Heterotopia (2019)
Journal Article
Vontell, R., Supramaniam, V. G., Davidson, A., Thornton, C., Marnerides, A., Holder-Espinasse, M., Lillis, S., Yau, S., Jansson, M., Hagberg, H. E., & Rutherford, M. A. (2019). Post-mortem Characterisation of a Case With an ACTG1 Variant, Agenesis of the Corpus Callosum and Neuronal Heterotopia. Frontiers in Physiology, 10, https://doi.org/10.3389/fphys.2019.00623

Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia whic... Read More about Post-mortem Characterisation of a Case With an ACTG1 Variant, Agenesis of the Corpus Callosum and Neuronal Heterotopia.

Evolutionary integration and modularity in the archosaur cranium (2019)
Journal Article
Felice, R. N., Watanabe, A., Cuff, A. R., Noirault, E., Pol, D., Witmer, L. M., Norell, M. A., O'Connor, P. M., & Goswami, A. (2019). Evolutionary integration and modularity in the archosaur cranium. Integrative and Comparative Biology, https://doi.org/10.1093/icb/icz052

Complex structures, like the vertebrate skull, are composed of numerous elements or traits that must develop and evolve in a coordinated manner to achieve multiple functions. The strength of association among phenotypic traits (i.e., integration), an... Read More about Evolutionary integration and modularity in the archosaur cranium.