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Chronic kidney disease in aged cats: Clinical features, morphology, and proposed pathogeneses (2016)
Journal Article
Brown, C., Elliott, J., Schmiedt, C., & Brown, S. (2016). Chronic kidney disease in aged cats: Clinical features, morphology, and proposed pathogeneses. Veterinary Pathology, 53(2), 309-326. https://doi.org/10.1177/0300985815622975

Chronic kidney disease (CKD) is the most common metabolic disease of domesticated cats, with most affected cats being geriatric (>12 years of age). The prevalence of CKD in cats exceeds that observed in dogs, and the frequency of the diagnosis of CKD... Read More about Chronic kidney disease in aged cats: Clinical features, morphology, and proposed pathogeneses.

Addition of magnesium sulphate to ropivacaine for spinal analgesia in dogs undergoing tibial plateau levelling osteotomy (2016)
Journal Article
Adami, C., Casoni, D., Noussitou, F., Rytz, U., & Spadavecchia, C. (2016). Addition of magnesium sulphate to ropivacaine for spinal analgesia in dogs undergoing tibial plateau levelling osteotomy. https://doi.org/10.1016/j.tvjl.2015.11.017

The aim of this blinded, randomised, prospective clinical trial was to determine whether the addition of magnesium sulphate to spinally-administered ropivacaine would improve peri-operative analgesia without impairing motor function in dogs undergoin... Read More about Addition of magnesium sulphate to ropivacaine for spinal analgesia in dogs undergoing tibial plateau levelling osteotomy.

Serum Biochemical Phenotypes in the Domestic Dog (2016)
Journal Article
Chang, Y. M., Hadox, E., Szladovits, B., & Garden, O. A. (2016). Serum Biochemical Phenotypes in the Domestic Dog. PLoS ONE, 11(2), e0149650. https://doi.org/10.1371/journal.pone.0149650

The serum or plasma biochemical profile is essential in the diagnosis and monitoring of systemic disease in veterinary medicine, but current reference intervals typically take no account of breed-specific differences. Breed-specific hematological phe... Read More about Serum Biochemical Phenotypes in the Domestic Dog.

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease (2016)
Journal Article
Deas, E., Cremades, N., Angelova, P. R., Ludtmann, M. H. R., Yao, Z., Chen, S., Horrocks, M. H., Banushi, B., Little, D., Devine, M. J., Gissen, P., Klenerman, D., Dobson, C. M., Wood, N. W., Gandhi, S., & Abramov, A. Y. (2016). Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. https://doi.org/10.1089/ars.2015.6343

Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregati... Read More about Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.

Prenatal muscle development in a mouse model for the secondary dystroglycanopathies (2016)
Journal Article
Kim, J., Hopkinson, M., Kavishwar, M., Fernandez-Fuente, M., & Brown, S. C. (2016). Prenatal muscle development in a mouse model for the secondary dystroglycanopathies. Skeletal Muscle, 6(3), https://doi.org/10.1186/s13395-016-0073-y

The defective glycosylation of α-dystroglycan is associated with a group of muscular dystrophies that are collectively referred to as the secondary dystroglycanopathies. Mutations in the gene encoding fukutin-related protein (FKRP) are one of the mos... Read More about Prenatal muscle development in a mouse model for the secondary dystroglycanopathies.

Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection (2016)
Journal Article
Crellen, T., Allan, F., David, S., Durrant, C., Huckvale, T., Holroyd, N., Emery, A. M., Rollinson, D., Aanensen, D. M., Berriman, M., Webster, J. P., & Cotton, J. A. (2016). Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection. https://doi.org/10.1038/srep20954

Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing data from 10 global isolates and an i... Read More about Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.

Opportunities for improving animal welfare in rodent models of epilepsy and seizures (2016)
Journal Article
Lidster, K., Jefferys, J. G., Blumcke, I., Crunelli, V., Flecknell, P. A., Frenguelli, B. G., Gray, W. P., Kaminski, R., Pitkaenen, A., Ragan, I., Shah, M., Imonato, M., Trevelyan, A., Volk, H. A., Walker, M., Yates, N., & Prescott, M. J. (2016). Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods, 260, 2-25. https://doi.org/10.1016/j.jneumeth.2015.09.007

Urinary active transforming growth factor ß in feline chronic kidney disease (2016)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2016). Urinary active transforming growth factor ß in feline chronic kidney disease. https://doi.org/10.1016/j.tvjl.2016.02.004

The cytokine transforming growth factor beta 1 (TGF-β1) has been widely implicated in the development and progression of renal fibrosis in chronic kidney disease (CKD) in humans and in experimental models. The aims of this study were to assess the as... Read More about Urinary active transforming growth factor ß in feline chronic kidney disease.

Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro (2016)
Journal Article
Hajjawi, M. O. R., Patel, J. J., Corcelli, M., Arnett, T. R., & Orriss, I. R. (2016). Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro. Purinergic Signalling, 12(2), 247-258. https://doi.org/10.1007/s11302-016-9499-2

Extracellular ATP, signalling through P2 receptors, exerts well-documented effects on bone cells, inhibiting mineral deposition by osteoblasts and stimulating the formation and resorptive activity of osteoclasts. The aims of this study were to determ... Read More about Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro.

Risk factors for cluster seizures in canine idiopathic epilepsy (2016)
Journal Article
Packer, R. M. A., Shihab, N. K., Torres, B. B. J., & Volk, H. A. (2016). Risk factors for cluster seizures in canine idiopathic epilepsy. Research in Veterinary Science, 105, 136-138. https://doi.org/10.1016/j.rvsc.2016.02.005

Cluster seizures (CS), two or more seizures within a 24-hour period, are reported in 38–77% of dogs with idiopathic epilepsy (IE). Negative outcomes associated with CS include a reduced likelihood of achieving seizure freedom, decreased survival time... Read More about Risk factors for cluster seizures in canine idiopathic epilepsy.

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition (2016)
Journal Article
Thorpe, C. T., Peffers, M. J., Simpson, D., Hallwell, E., Screen, H. R., & Clegg, P. D. (2016). Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. https://doi.org/10.1038/srep20455

Tendon is a simple aligned fibre composite, consisting of collagen-rich fascicles surrounded by a softer interfascicular matrix (IFM). The composition and interactions between these material phases are fundamental in ensuring tissue mechanics meet fu... Read More about Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition.

The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice (2016)
Journal Article
Heppolette, C. A. A., Chen, J.-H., Carr, S. K., Palmer, D. B., & Ozanne, S. E. (2016). The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget, 7(6), 6398-6409. https://doi.org/10.18632/oncotarget.7176

Environmental factors such as nutrition during early life can influence long-term health, a concept termed developmental programming. Initial research was focused towards the effects on metabolic health but more recent studies have demonstrated effec... Read More about The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice.