The global antigenic diversity of swine influenza A viruses

Lewis, N S; Russell, C A; Langat, P; Anderson, T K; Berger, K; Bielejec, F; Burke, D F; Dudas, G; Fonville, J M; Fouchier, R A; Kellam, P; Koel, B F; Lemey, P; Nguyen, T; Nuansrichy, B; Peiris, J M; Saito, T; Simon, G; Skepner, E; Takemae, N; ESNIP3 Consortium; Webby, R J; Van Reeth, K; Brookes, S M; Larsen, L; Watson, S J; Brown, I H; Vincent, A L

doi:10.7554/eLife.12217

The global antigenic diversity of swine influenza A viruses

Lewis, N S; Russell, C A; Langat, P; Anderson, T K; Berger, K; Bielejec, F; Burke, D F; Dudas, G; Fonville, J M; Fouchier, R A; Kellam, P; Koel, B F; Lemey, P; Nguyen, T; Nuansrichy, B; Peiris, J M; Saito, T; Simon, G; Skepner, E; Takemae, N; ESNIP3 Consortium; Webby, R J; Van Reeth, K; Brookes, S M; Larsen, L; Watson, S J; Brown, I H; Vincent, A L

Authors

N S Lewis

C A Russell

P Langat

T K Anderson

K Berger

F Bielejec

D F Burke

G Dudas

J M Fonville

R A Fouchier

P Kellam

B F Koel

P Lemey

T Nguyen

B Nuansrichy

J M Peiris

T Saito

G Simon

E Skepner

N Takemae

ESNIP3 Consortium

R J Webby

K Van Reeth

S M Brookes

L Larsen

S J Watson

I H Brown

A L Vincent

Abstract

wine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.

Citation

Lewis, N. S., Russell, C. A., Langat, P., Anderson, T. K., Berger, K., Bielejec, F., …Vincent, A. L. (2016). The global antigenic diversity of swine influenza A viruses. eLife, 5, e12217. https://doi.org/10.7554/eLife.12217

Journal Article Type	Article
Acceptance Date	Mar 23, 2016
Publication Date	Apr 22, 2016
Deposit Date	Aug 21, 2018
Publicly Available Date	Aug 23, 2018
Journal	eLife
Publisher	eLife Sciences Publications
Peer Reviewed	Peer Reviewed
Volume	5
Pages	e12217
DOI	https://doi.org/10.7554/eLife.12217
Public URL	https://rvc-repository.worktribe.com/output/1396916