DNA methylation networks underlying mammalian traits
(2023)
Journal Article
Haghani, A., Li, C. Z., Robeck, T. R., Zhang, J., Lu, A. T., Ablaeva, J., …Horvath, S. (2023). DNA methylation networks underlying mammalian traits. Science, 381(6658), https://doi.org/10.1126/science.abq5693
All Outputs (38)
Universal DNA methylation age across mammalian tissues (2023)
Journal Article
Lu, A. T., Fei, Z., Haghani, A., Robeck, T. R., Zoller, J. A., Li, C. Z., …Horvath, S. (in press). Universal DNA methylation age across mammalian tissues. Nature Aging, 3(9), 1144-1166. https://doi.org/10.1038/s43587-023-00462-6
Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia (2023)
Journal Article
Glanemann, B., Humm, K., Szladovits, B., Abreu, M., Aspnall, S., Buckeridge, D., …Wilson, H. (in press). Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia. Journal of Veterinary Internal Medicine, 126-132. https://doi.org/10.1111/jvim.16613Backgound: After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato- and myelotoxic mycotoxins T-2, HT-2 and diac... Read More about Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia.
Morphologic, cytochemical, and ultrastructural features of gray eosinophils in nine cats (2021)
Journal Article
Holmes, E., Raskin, R., McGill, P., & Szladovits, B. (2021). Morphologic, cytochemical, and ultrastructural features of gray eosinophils in nine cats. Veterinary Clinical Pathology, 50(1), 52-56. https://doi.org/10.1111/vcp.12950Background Gray eosinophils, resembling those in sighthound dog breeds, have not previously been reported in cats. Objectives We aimed to provide a morphologic, cytochemical, and ultrastructural description of gray eosinophils in cats. Methods Blood... Read More about Morphologic, cytochemical, and ultrastructural features of gray eosinophils in nine cats.
Epigenetic clock and methylation studies in cats (2021)
Journal Article
Raj, K., Szladovits, B., Haghani, A., Zoller, J., Li, C., Black, P., …Horvath, S. (2021). Epigenetic clock and methylation studies in cats. GeroScience, https://doi.org/10.1007/s11357-021-00445-8Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging ("epigenetic clocks"). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principle... Read More about Epigenetic clock and methylation studies in cats.
Breed predispositions, clinical findings, and prognostic factors for death in dogs with nonregenerative immune‐mediated anemia (2020)
Journal Article
Szladovits, B., & Glanemann, B. (in press). Breed predispositions, clinical findings, and prognostic factors for death in dogs with nonregenerative immune‐mediated anemia. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15986Abstract Background: Breed predispositions, survival, and prognostic factors have not been evaluated in dogs with nonregenerative immune-mediated anemia (nrIMA). Hypothesis/Objectives: To describe clinicopathologic variables, evaluate their associa... Read More about Breed predispositions, clinical findings, and prognostic factors for death in dogs with nonregenerative immune‐mediated anemia.
Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation (2020)
Journal Article
Wu, Y., Chang, Y. M., Polton, G., Stell, A. J., Szladovits, B., Macfarlane, M., …Garden, O. A. (2020). Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00307Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs. Two DLBCL subtypes based on cell of origin are generally recognized, germinal center B (GCB)-like and activated B cell (A... Read More about Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation.
The utility of diagnostic tests for immune-mediated hemolytic anemia (2019)
Journal Article
Members Of The Veterinary And Comparative Clinical Immunology So, , MacNeill, A. L., Dandrieux, J., Lubas, G., Seelig, D., & Szladovits, B. (2019). The utility of diagnostic tests for immune-mediated hemolytic anemia. Veterinary Clinical Pathology, 48(S1), 7-16. https://doi.org/10.1111/vcp.12771
Abdominal CT evaluation of the liver and spleen for staging mast cell tumors in dogs yields nonspecific results (2019)
Journal Article
Hughes, J. R., Szladovits, B., & Drees, R. (2019). Abdominal CT evaluation of the liver and spleen for staging mast cell tumors in dogs yields nonspecific results. https://doi.org/10.1111/vru.12717Canine mast cell tumor staging is commonly performed using abdominal ultrasonography and fine‐needle aspiration cytology of masses, lymph nodes, and hepatic and splenic parenchyma. Computed tomography is used for abdominal, thoracic, or whole body im... Read More about Abdominal CT evaluation of the liver and spleen for staging mast cell tumors in dogs yields nonspecific results.
Hepatozoon canis in three imported dogs: a new tickborne disease reaching the United Kingdom (2018)
Journal Article
Attipa, C., Maguire, D., Solano-Gallego, L., Szladovits, B., Barker, E. N., Farr, A., …Tasker, S. (2018). Hepatozoon canis in three imported dogs: a new tickborne disease reaching the United Kingdom. Veterinary Record, 183(716), https://doi.org/10.1136/vr.105087An increasing number of non-endemic vectorborne pathogens have been described in dogs imported to the UK in the past two decades. Recently, an outbreak of canine babesiosis in south-east England has raised veterinary awareness with regard to the impa... Read More about Hepatozoon canis in three imported dogs: a new tickborne disease reaching the United Kingdom.
Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat (2018)
Journal Article
Attipa, C., Beck, S., Lipscomb, V. J., English, K., Carvalho, S., Kiupel, M., …Peters, L. M. (2018). Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat. Veterinary Clinical Pathology, 47(4), 660-664. https://doi.org/10.1111/vcp.12658A 10‐year‐old male neutered Persian cat was presented with an abdominal mass and history of weakness. Blood smear examination found marked elliptocytosis, and serum biochemical analysis revealed hypokalemia, hypochloremia, increased creatine kinase a... Read More about Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat.
Comparison of medical and/or surgical management of 23 cats with intracranial empyema or abscessation (2018)
Journal Article
Martin, S., Drees, R., Szladovits, B., & Beltran, E. (2018). Comparison of medical and/or surgical management of 23 cats with intracranial empyema or abscessation. Journal of Feline Medicine and Surgery, 21(6), 566-574. https://doi.org/10.1177/1098612X18792657
Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry (2018)
Journal Article
Pittaway, R., Wu, Y., Suárez-Bonnet, A., Szladovits, B., Scurrell, E. J., Garden, O. A., …Priestnall, S. L. (2018). Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry. Journal of Veterinary Diagnostic Investigation, https://doi.org/10.1177/1040638718760965Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30. Null-cell lymphoma has also been described in dogs when neither... Read More about Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry.
Feline primary erythrocytosis: a multicentre case series of 18 cats (2018)
Journal Article
Darcy, H., Simpson, K., Gajanayake, I., Seth, M., McGrotty, Y., Szladovits, B., & Glanemann, B. (2018). Feline primary erythrocytosis: a multicentre case series of 18 cats. Journal of Feline Medicine and Surgery, https://doi.org/10.1177/1098612X17750333A retrospective multicentre case series of feline primary erythrocytosis (PE) was evaluated. The aim was to gain better understanding of disease presentation and progression to guide management and prognostication. Case records were assessed for evid... Read More about Feline primary erythrocytosis: a multicentre case series of 18 cats.
Leptin and ghrelin concentration in hyperthyroid cats before and after radioactive iodine therapy compared to euthyroid control cats (2018)
Journal Article
Marsilio, S., Glanemann, B., Martin, L., Szladovits, B., & Neiger, R. (2018). Leptin and ghrelin concentration in hyperthyroid cats before and after radioactive iodine therapy compared to euthyroid control cats. https://doi.org/10.15654/TPK-160333
Prognostic significance of clinical presentation, induction and rescue treatment in 42 cases of canine centroblastic diffuse large B-cell multicentric lymphoma in the United Kingdom (2018)
Journal Article
Davies, O., Szladovits, B., Polton, G., Garden, O. A., Leo, C., & Lara-Garcia, A. (2018). Prognostic significance of clinical presentation, induction and rescue treatment in 42 cases of canine centroblastic diffuse large B-cell multicentric lymphoma in the United Kingdom. Veterinary and Comparative Oncology, 16(2), 276-287. https://doi.org/10.1111/vco.12378Canine lymphoma is a heterogeneous group of diseases and many previous studies have evaluated the response of a mixed population of lymphoma cases to one specific treatment protocol. The aim of this retrospective study was to describe the outcome and... Read More about Prognostic significance of clinical presentation, induction and rescue treatment in 42 cases of canine centroblastic diffuse large B-cell multicentric lymphoma in the United Kingdom.
Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat (2017)
Journal Article
Heaps, L. A., Scudder, C. J., Lipscomb, V. J., Steinbach, S. M. L., Priestnall, S. L., Martineau, H., …Garden, O. A. (2017). Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat. Journal of Feline Medicine and Surgery Open Reports, 32(2), https://doi.org/10.1177/2055116917722701
Serum Biochemical Phenotypes in the Domestic Dog (2016)
Journal Article
Chang, Y. M., Hadox, E., Szladovits, B., & Garden, O. A. (2016). Serum Biochemical Phenotypes in the Domestic Dog. PLoS ONE, 11(2), e0149650. https://doi.org/10.1371/journal.pone.0149650The serum or plasma biochemical profile is essential in the diagnosis and monitoring of systemic disease in veterinary medicine, but current reference intervals typically take no account of breed-specific differences. Breed-specific hematological phe... Read More about Serum Biochemical Phenotypes in the Domestic Dog.
Cytological Findings of 140 Bile Samples from Dogs and Cats and Associated Clinical Pathological Data (2016)
Journal Article
Peters, L. M., Glanemann, B., Garden, O. A., & Szladovits, B. (2016). Cytological Findings of 140 Bile Samples from Dogs and Cats and Associated Clinical Pathological Data. Journal of Veterinary Internal Medicine, 30(1), 123-31. https://doi.org/10.1111/jvim.13645
Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma (2014)
Journal Article
Pinheiro, D. Y., Chang, Y. M., Bryant, H., Szladovits, B., Dalessandri, T., Davison, L. J., …Garden, O. A. (2014). Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma. PLoS ONE, 9(8), e105027. https://doi.org/10.1371/journal.pone.0105027The cancer microenvironment plays a pivotal role in oncogenesis, containing a number of regulatory cells that attenuate the anti-neoplastic immune response. While the negative prognostic impact of regulatory T cells (Tregs) in the context of most sol... Read More about Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma.