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Is the incidence of congenital toxoplasmosis declining? (2022)
Journal Article
Milne, G., Webster, J., & Walker, M. (2022). Is the incidence of congenital toxoplasmosis declining?. Trends in Parasitology, 39(1), 26-37. https://doi.org/10.1016/j.pt.2022.10.003

Prenatal infection with the protozoan parasite Toxoplasma gondii can cause con-genital toxoplasmosis (CT), an often fatal or lifelong-disabling condition. Several studies of human populations have reported temporal decreases in seroprevalence, sugges... Read More about Is the incidence of congenital toxoplasmosis declining?.

In vivo efficiency of praziquantel treatment of single-sex Schistosoma three months old in mice (2022)
Journal Article
Wang, N., Peng, H., Gao, C., Cheng, Y., Sun, M., Qu, G., …Lu, D. (2022). In vivo efficiency of praziquantel treatment of single-sex Schistosoma three months old in mice. International Journal for Parasitology: Drugs and Drug Resistance, 20, 129-134. https://doi.org/10.1016/j.ijpddr.2022.11.002

Schistosomiasis is a major neglected tropical disease mainly caused by Schistosoma haematobium, S. japonicum and S. mansoni, and results in the greatest disease burden. Mass drug administration (MDA) with praziquantel (PZQ), a single drug only availa... Read More about In vivo efficiency of praziquantel treatment of single-sex Schistosoma three months old in mice.

Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands (2022)
Journal Article
Pennance, T., Neves, M. I., Webster, B. L., Gower, C. M., Knopp, S., Khamis, I. S., …Webster, J. P. (2022). Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands. PLoS Neglected Tropical Diseases, 16(10), e0010419. https://doi.org/10.1371/journal.pntd.0010419

Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance (2022)
Journal Article
Díaz, A. V., Lambert, S., Neves, M. I., Borlase, A., Léger, E., Diouf, N. D., …Walker, M. (2022). Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance. Frontiers in Tropical Diseases, 3, 1-12. https://doi.org/10.3389/fitd.2022.893066

Schistosomiasis, a neglected tropical disease, is a widespread chronic helminthiasis reported in 78 countries, predominantly those within sub-Saharan Africa, as well as Latin America, Asia, and most recently, even Europe. Species of the causative blo... Read More about Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance.

Endogenous Viral Elements in Shrew Genomes Provide Insights into Pestivirus Ancient History (2022)
Journal Article
Li, Y., Bletsa, M., Zisi, Z., Boonen, I., Gryseels, S., Kafetzopoulou, L., …Lequime, S. (2022). Endogenous Viral Elements in Shrew Genomes Provide Insights into Pestivirus Ancient History. Molecular Biology and Evolution, 39(10), https://doi.org/10.1093/molbev/msac190

As viral genomic imprints in host genomes, endogenous viral elements (EVEs) shed light on the deep evolutionary history of viruses, ancestral host ranges, and ancient viral-host interactions. In addition, they may provide crucial information for cali... Read More about Endogenous Viral Elements in Shrew Genomes Provide Insights into Pestivirus Ancient History.

Estimating the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers keeping cattle, sheep and goats in northern Senegal (2022)
Journal Article
Adeyemo, P., Léger, E., Hollenberg, E., Diouf, N., Sène, M., Webster, J. P., & Häsler, B. (2022). Estimating the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers keeping cattle, sheep and goats in northern Senegal. Parasites and Vectors, 15(1), https://doi.org/10.1186/s13071-021-05147-w

Background: Schistosomiasis is a disease that poses major threats to human and animal health, as well as the economy, especially in sub-Saharan Africa (SSA). Whilst many studies have evaluated the economic impact of schistosomiasis in humans, to dat... Read More about Estimating the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers keeping cattle, sheep and goats in northern Senegal.

Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa (2020)
Journal Article
Webster, J. P., Neves, M. I., Webster, B. L., Pennance, T., Rabone, M., Gouvras, A. N., …Rollinson, D. (2020). Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa. American Journal of Tropical Medicine and Hygiene, https://doi.org/10.4269/ajtmh.19-0827

Analyses of the population genetic structure of schistosomes under the “Schistosomiasis Consortium for Operational Research and Evaluation” (SCORE) contrasting treatment pressure scenarios in Tanzania, Niger, and Zanzibar were performed to provide su... Read More about Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa.

Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018 (2020)
Journal Article
Catalano, S., Léger, E., Fall, C. B., Borlase, A., Diop, S. D., Berger, D., …Webster, J. P. (2020). Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018. Emerging Infectious Disease, 26(6), https://doi.org/10.3201/eid2606.200107

In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collecte... Read More about Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018.

Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools (2020)
Journal Article
Walker, M., Webster, J. P., & Milne, G. (2020). Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools. Clinical Infectious Diseases, https://doi.org/10.1093/cid/ciaa428

Background. Horizontal transmission of Toxoplasma gondii occurs primarily via ingestion of environmental oocysts or con- sumption of undercooked/raw meat containing cyst-stage bradyzoites. The relative importance of these 2 transmission routes remain... Read More about Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools.

Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale (2020)
Journal Article
Jones, B. P., Norman, B. F., Borrett, H. E., Attwood, S. W., Mondal, M. M. H., Walker, A. J., …Lawton, S. P. (2020). Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale. https://doi.org/10.1038/s41598-020-57736-x

Schistosoma spindale and Schistosoma indicum are ruminant-infecting trematodes of the Schistosoma indicum group that are widespread across Southeast Asia. Though neglected, these parasites can cause major pathology and mortality to livestock leading... Read More about Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale.

Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda (2019)
Journal Article
Faust, C. L., Crotti, M., Moses, A., Oguttu, D., Wamboko, A., Adriko, M., …Lamberton, P. H. L. (2019). Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda. https://doi.org/10.1186/s13071-019-3860-6

Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission (2019)
Journal Article
Wood, C. L., Sokolow, S. H., Jones, I. J., Chamberlin, A. J., Lafferty, K. D., Kuris, A. M., …De Leo, G. A. (2019). Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission. Proceedings of the National Academy of Sciences, 116(46), 23182-23191. https://doi.org/10.1073/pnas.1903698116

Recently, the World Health Organization recognized that efforts to interrupt schistosomiasis transmission through mass drug administration have been ineffective in some regions; one of their new recommended strategies for global schistosomiasis contr... Read More about Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission.

Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing (2019)
Journal Article
Doyle, S. R., Sankaranarayanan, G., Allan, F., Berger, D., Jimenez Castro, P. D., Collins, J. B., …Holroyd, N. (2019). Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing. Frontiers in Genetics, 10, https://doi.org/10.3389/fgene.2019.00826

Whole-genome sequencing is being rapidly applied to the study of helminth genomes, including de novo genome assembly, population genetics, and diagnostic applications. Although late-stage juvenile and adult parasites typically produce sufficient DNA... Read More about Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing.

Mini-FLOTAC as an alternative, non-invasive diagnostic tool for Schistosoma mansoni and other trematode infections in wildlife reservoirs (2019)
Journal Article
Catalano, S., Symeou, A., Marsh, K. J., Borlase, A., Léger, E., Fall, C. B., …Webster, J. P. (2019). Mini-FLOTAC as an alternative, non-invasive diagnostic tool for Schistosoma mansoni and other trematode infections in wildlife reservoirs. https://doi.org/10.1186/s13071-019-3613-6

Schistosomiasis and food-borne trematodiases are not only of major public health concern, but can also have profound implications for livestock production and wildlife conservation. The zoonotic, multi-host nature of many digenean trematodes is a sig... Read More about Mini-FLOTAC as an alternative, non-invasive diagnostic tool for Schistosoma mansoni and other trematode infections in wildlife reservoirs.

The association between child Schistosoma spp. infections and morbidity in an irrigated rice region in Mali: a localized study (2019)
Journal Article
Mutombo, N., Landouré, A., Young Man, W., Fenwick, A., Dembélé, R., Sacko, M., …McLaws, M. (2019). The association between child Schistosoma spp. infections and morbidity in an irrigated rice region in Mali: a localized study. Acta Tropica, 199, https://doi.org/10.1016/j.actatropica.2019.105115

Schistosomiasis is one of the neglected tropical diseases endemic to Mali. There has been insufficient investigation of the morbidity burden in highly endemic irrigated rice areas with the ongoing mass drug administration with praziquantel. In Februa... Read More about The association between child Schistosoma spp. infections and morbidity in an irrigated rice region in Mali: a localized study.

Population genetics of Oncomelania hupensis snails, intermediate hosts of Schistosoma japonium, from emerging, re-emerging or established habitats within China (2019)
Journal Article
Qiu, C., Lu, D., Deng, Y., Zou, H., Liang, Y., & Webster, J. P. (2019). Population genetics of Oncomelania hupensis snails, intermediate hosts of Schistosoma japonium, from emerging, re-emerging or established habitats within China. Acta Tropica, 197, 105048. https://doi.org/10.1016/j.actatropica.2019.105048

Schistosomiasis remains one of the world’s most significant neglected tropical diseases, second only to malaria in terms of socioeconomic impact. In 2014, China proposed the goal of schistosomiasis japonicum elimination by 2025. However, one major ch... Read More about Population genetics of Oncomelania hupensis snails, intermediate hosts of Schistosoma japonium, from emerging, re-emerging or established habitats within China.

Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand (2019)
Journal Article
Suwannahitatorn, P., Webster, J. P., Riley, S., Mungthin, M., & Donnelly, C. A. (2019). Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand. PLoS ONE, 14(1), e0211540. https://doi.org/10.1371/journal.pone.0211540

In contrast to northern and northeastern Thailand, central Thailand was believed not to be endemic for Opisthorchis viverrini (OV). Fieldwork conducted in a rural area of central Thailand revealed that the prevalence and incidence were relatively hig... Read More about Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand.