All Outputs (101)

Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective (2023)
Journal Article
Diaz, A., Walker, M., & Webster, J. (2023). Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective. Philosophical Transactions of the Royal Society B: Biological Sciences, 378(1887), https://doi.org/10.1098/rstb.2022.0274

The past three years has seen the launch of a new World Health Organization (WHO) neglected tropical diseases (NTDs) roadmap, together with revised control and elimination guidelines. Across all, there is now a clear emphasis on the need to incorpora... Read More about Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective.

Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health (2023)
Journal Article
Qiu, Y., Guitian, J., Webster, J., Musallam, I., Haider, N., Drewe, J., & Song, J. (2023). Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health. Philosophical Transactions of the Royal Society B: Biological Sciences, 378(1887), https://doi.org/10.1098/rstb.2022.0407

Zoonotic diseases (zoonoses) originating from domestic animals pose a significant risk to people's health and livelihoods, in addition to jeopardizing animal health and production. Effective surveillance of endemic zoonoses at the animal level is cru... Read More about Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health.

Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis (2023)
Journal Article
Calvo-Urbano, B., Leger, E., Gabain, I., De Dood, C., Diouf, N., Borlase, A., Rudge, J., Corstjens, P., Sene, M., Van Dam, G., Walker, M., & Webster, J. (2023). Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis. PLoS Neglected Tropical Diseases, 17(5), https://doi.org/10.1371/journal.pntd.0010739

Schistosomiasis is a major neglected tropical disease (NTD) affecting both humans and animals. The morbidity and mortality inflicted upon livestock in the Afrotropical region has been largely overlooked, in part due to a lack of validated sensitive a... Read More about Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis.

Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth (2023)
Journal Article
Kadia, B., Otiti, M., Ramsteijn, A., Sow, D., Faye, B., Heffernan, C., Hall, L., Webster, J., Walker, A., & Allen, S. (2023). Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth. Nutrition Reviews, https://doi.org/10.1093/nutrit/nuad050

In children exposed to poor hygiene and sanitation, invasion of the gut by pathogenic microbes can result in a subclinical enteropathy termed "environmental enteric dysfunction" (EED) that contributes to undernutrition, growth faltering, and impaired... Read More about Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth.

Evolution of tetraspanin antigens in the zoonotic Asian blood fluke Schistosoma japonicum (2023)
Journal Article
Parsons, D., Walker, A., Emery, A., Webster, J., & Lawton, S. (2023). Evolution of tetraspanin antigens in the zoonotic Asian blood fluke Schistosoma japonicum. Parasites and Vectors, 16(1), https://doi.org/10.1186/s13071-023-05706-3

BackgroundDespite successful control efforts in China over the past 60 years, zoonotic schistosomiasis caused by Schistosoma japonicum remains a threat with transmission ongoing and the risk of localised resurgences prompting calls for a novel integr... Read More about Evolution of tetraspanin antigens in the zoonotic Asian blood fluke Schistosoma japonicum.

Is the incidence of congenital toxoplasmosis declining? (2022)
Journal Article
Milne, G., Webster, J., & Walker, M. (2022). Is the incidence of congenital toxoplasmosis declining?. Trends in Parasitology, 39(1), 26-37. https://doi.org/10.1016/j.pt.2022.10.003

Prenatal infection with the protozoan parasite Toxoplasma gondii can cause con-genital toxoplasmosis (CT), an often fatal or lifelong-disabling condition. Several studies of human populations have reported temporal decreases in seroprevalence, sugges... Read More about Is the incidence of congenital toxoplasmosis declining?.

In vivo efficiency of praziquantel treatment of single-sex Schistosoma three months old in mice (2022)
Journal Article
Wang, N., Peng, H., Gao, C., Cheng, Y., Sun, M., Qu, G., Webster, J., & Lu, D. (2022). In vivo efficiency of praziquantel treatment of single-sex Schistosoma three months old in mice. International Journal for Parasitology: Drugs and Drug Resistance, 20, 129-134. https://doi.org/10.1016/j.ijpddr.2022.11.002

Schistosomiasis is a major neglected tropical disease mainly caused by Schistosoma haematobium, S. japonicum and S. mansoni, and results in the greatest disease burden. Mass drug administration (MDA) with praziquantel (PZQ), a single drug only availa... Read More about In vivo efficiency of praziquantel treatment of single-sex Schistosoma three months old in mice.

Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands (2022)
Journal Article
Pennance, T., Neves, M. I., Webster, B. L., Gower, C. M., Knopp, S., Khamis, I. S., Ame, S. M., Ali, S. M., Rabone, M., Emery, A., Allan, F., Muhsin, M. A., Suleiman, K. R., Kabole, F., Walker, M., Rollinson, D., & Webster, J. P. (2022). Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands. PLoS Neglected Tropical Diseases, 16(10), e0010419. https://doi.org/10.1371/journal.pntd.0010419

Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance (2022)
Journal Article
Díaz, A. V., Lambert, S., Neves, M. I., Borlase, A., Léger, E., Diouf, N. D., Sène, M., Webster, J. P., & Walker, M. (2022). Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance. Frontiers in Tropical Diseases, 3, 1-12. https://doi.org/10.3389/fitd.2022.893066

Schistosomiasis, a neglected tropical disease, is a widespread chronic helminthiasis reported in 78 countries, predominantly those within sub-Saharan Africa, as well as Latin America, Asia, and most recently, even Europe. Species of the causative blo... Read More about Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance.

Endogenous Viral Elements in Shrew Genomes Provide Insights into Pestivirus Ancient History (2022)
Journal Article
Li, Y., Bletsa, M., Zisi, Z., Boonen, I., Gryseels, S., Kafetzopoulou, L., Webster, J., Catalano, S., Pybus, O., Van de Perre, F., Li, H., Li, Y., Li, Y., Abramov, A., Lymberakis, P., Lemey, P., & Lequime, S. (2022). Endogenous Viral Elements in Shrew Genomes Provide Insights into Pestivirus Ancient History. Molecular Biology and Evolution, 39(10), https://doi.org/10.1093/molbev/msac190

As viral genomic imprints in host genomes, endogenous viral elements (EVEs) shed light on the deep evolutionary history of viruses, ancestral host ranges, and ancient viral-host interactions. In addition, they may provide crucial information for cali... Read More about Endogenous Viral Elements in Shrew Genomes Provide Insights into Pestivirus Ancient History.

Systematic review to evaluate a potential association between helminth infection and physical stunting in children (2022)
Journal Article
Raj, E., Calvo-Urbano, B., Heffernan, C., Halder, J., & Webster, J. (2022). Systematic review to evaluate a potential association between helminth infection and physical stunting in children. Parasites and Vectors, 15(1), https://doi.org/10.1186/s13071-022-05235-5

Background: Despite considerable public health efforts over the past 20 years, childhood stunting (physical and/or cognitive) levels globally remain unacceptably high-at 22% amongst children under 5 years old in 2020. The aetiology of stunting is com... Read More about Systematic review to evaluate a potential association between helminth infection and physical stunting in children.

Estimating the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers keeping cattle, sheep and goats in northern Senegal (2022)
Journal Article
Adeyemo, P., Léger, E., Hollenberg, E., Diouf, N., Sène, M., Webster, J. P., & Häsler, B. (2022). Estimating the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers keeping cattle, sheep and goats in northern Senegal. Parasites and Vectors, 15(1), https://doi.org/10.1186/s13071-021-05147-w

Background: Schistosomiasis is a disease that poses major threats to human and animal health, as well as the
economy, especially in sub-Saharan Africa (SSA). Whilst many studies have evaluated the economic impact of schistosomiasis in humans, to dat... Read More about Estimating the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers keeping cattle, sheep and goats in northern Senegal.

Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni (2022)
Journal Article
Platt, R., Le Clec'h, W., Chevalier, F., McDew-White, M., LoVerde, P., de Assis, R., Oliveira, G., Kinung'hi, S., Djirmay, A., Steinauer, M., Gouvras, A., Rabone, M., Allan, F., Webster, B., Webster, J., Emery, A., Rollinson, D., & Anderson, T. (2022). Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni. Molecular Ecology, 31(8), 2242-2263. https://doi.org/10.1111/mec.16395

Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data (2022)
Journal Article
Walker, M., Freitas, L. T., Halder, J. B., Brack, M., Keiser, J., King, C. H., Levecke, B., Ai-Lian Lim, Y., Pieri, O., Sow, D., Stothard, J. R., Webster, J. P., Zhou, X.-N., Terry, R. F., Guérin, P. J., & Basáñez, M.-G. (in press). Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data. Wellcome Open Research, 7, 5. https://doi.org/10.12688/wellcomeopenres.17468.1

Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal (2021)
Journal Article
Fall, C., Lambert, S., Leger, E., Yasenev, L., Garba, A., Diop, S., Borlase, A., Catalano, S., Faye, B., Walker, M., Sene, M., & Webster, J. (2021). Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal. Microorganisms, 9(8), https://doi.org/10.3390/microorganisms9081776

Hybridization of infectious agents is a major emerging public and veterinary health concern at the interface of evolution, epidemiology, and control. Whilst evidence of the extent of hybridization amongst parasites is increasing, their impact on morb... Read More about Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal.

Spillover, hybridization, and persistence in schistosome transmission dynamics at the human-animal interface (2021)
Journal Article
Borlase, A., Rudge, J., Leger, E., Diouf, N., Fall, C., Diop, S., Catalano, S., Sene, M., & Webster, J. (2021). Spillover, hybridization, and persistence in schistosome transmission dynamics at the human-animal interface. Proceedings of the National Academy of Sciences, 118(41), https://doi.org/10.1073/pnas.2110711118

Zoonotic spillover and hybridization of parasites are major emerging public and veterinary health concerns at the interface of infectious disease biology, evolution, and control. Schistosomiasis is a neglected tropical disease of global importance ca... Read More about Spillover, hybridization, and persistence in schistosome transmission dynamics at the human-animal interface.

Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration (2021)
Journal Article
Berger, D., Crellen, T., Lamberton, P., Allan, F., Tracey, A., Noonan, J., Kabatereine, N., Tukahebwa, E., Adriko, M., Holroyd, N., Webster, J., Berriman, M., & Cotton, J. (2021). Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration. Nature Communications, 12(1), https://doi.org/10.1038/s41467-021-24958-0

Control and elimination of the parasitic disease schistosomiasis relies on mass administration of praziquantel. Whilst these programmes reduce infection prevalence and intensity, their impact on parasite transmission and evolution is poorly understoo... Read More about Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration.

Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective (2021)
Journal Article
Diaz, A., Walker, M., & Webster, J. (2021). Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective. Evolutionary Applications, https://doi.org/10.1111/eva.13310

The relevance of mustelids in SARS-CoV-2 transmission has become increasingly evident. Alongside experimental demonstration of airborne transmission among ferrets, the major animal model for human respiratory diseases, transmission of SARS-CoV-2 with... Read More about Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective.

Interactions between Schistosoma haematobium group species and their Bulinus spp. intermediate hosts along the Niger River Valley (2020)
Journal Article
Pennance, T., Allan, F., Emery, A., Rabone, M., Cable, J., Garba, A. D., Hamidou, A. A., Webster, J. P., Rollinson, D., & Webster, B. L. (2020). Interactions between Schistosoma haematobium group species and their Bulinus spp. intermediate hosts along the Niger River Valley. Parasites and Vectors, 13(1), https://doi.org/10.1186/s13071-020-04136-9

Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa (2020)
Journal Article
Webster, J. P., Neves, M. I., Webster, B. L., Pennance, T., Rabone, M., Gouvras, A. N., Allan, F., Walker, M., & Rollinson, D. (2020). Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa. American Journal of Tropical Medicine and Hygiene, https://doi.org/10.4269/ajtmh.19-0827

Analyses of the population genetic structure of schistosomes under the “Schistosomiasis Consortium for Operational Research and Evaluation” (SCORE) contrasting treatment pressure scenarios in Tanzania, Niger, and Zanzibar were performed to provide su... Read More about Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa.