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All Outputs (282)

Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease (2023)
Journal Article
Paschall, R., Quimby, J., Cianciolo, R., McLeland, S., Lunn, K., & Elliott, J. (2023). Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 37(2), 556-566. https://doi.org/10.1111/jvim.16656

BackgroundHypoxia is a key driver of fibrosis and is associated with capillary rarefaction in humans. ObjectivesCharacterize capillary rarefaction in cats with chronic kidney disease (CKD). AnimalsArchival kidney tissue from 58 cats with CKD, 20 unaf... Read More about Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease.

Relationships between total adiponectin concentrations and obesity in native-breed ponies in England (2023)
Journal Article
Barnabe, M., Elliott, J., Harris, P., & Menzies-Gow, N. (in press). Relationships between total adiponectin concentrations and obesity in native-breed ponies in England. Equine Veterinary Journal, https://doi.org/10.1111/evj.14013

Background: Equine metabolic syndrome is a collection of risk factors associated with an increased risk of endocrinopathic laminitis. All affected animals display insulin dysregulation and some may show adiponectin dysregulation and/or excessive adip... Read More about Relationships between total adiponectin concentrations and obesity in native-breed ponies in England.

Predictors of laminitis development in a cohort of nonlaminitic ponies (2023)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, Y., & Menzies-Gow, N. (2023). Predictors of laminitis development in a cohort of nonlaminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13572

Background Quantifying risk factors for laminitis development requires improvement. Objectives To identify the most useful physical examination, metabolic and management factors to predict laminitis development in client-owned, nonlaminitic ponies. S... Read More about Predictors of laminitis development in a cohort of nonlaminitic ponies.

Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study (2022)
Journal Article
Henze, L., Foth, S., Meller, S., Twele, F., Charalambous, M., Kenward, H., Elliott, J., Pelligand, L., & Volk, H. (2022). Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16504

Background: Nausea and emesis can be, among other signs, common manifestations
of acute vestibular system dysfunction in dogs. Currently, antiemetic drugs, such as
maropitant and metoclopramide, are used commonly, but do not appear to control
naus... Read More about Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018) (2022)
Journal Article
van den Broek, D., Geddes, R., Lotter, N., Chang, Y., Elliott, J., & Jepson, R. (2022). Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16430

Background Hypercalcemia is associated with chronic kidney disease (CKD) in cats, but studies assessing the physiologically relevant ionized calcium fraction are lacking. Objectives To describe the prevalence and incidence rate of ionized hypercalcem... Read More about Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018).

New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat (2022)
Journal Article
Elliott, J., & Geddes, R. F. (2022). New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat. The Veterinary Journal, 283-284, Article 105842. https://doi.org/10.1016/j.tvjl.2022.105842

New discoveries relating to phosphorus homeostasis include the hormones fibroblast growth factor-23 and klotho produced by bone and kidney. These hormones, together with novel understanding of how calcium and phosphate ions are carried in colloidal f... Read More about New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat.

Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib (2022)
Journal Article
Lees, P., Toutain, P., Elliott, J., Giraudel, J. M., Pelligand, L., & King, J. N. (2022). Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib. Journal of Veterinary Pharmacology and Therapeutics, 45(4), 325-351. https://doi.org/10.1111/jvp.13052

Robenacoxib is a veterinary-approved non-steroidal anti-inflammatory drug (NSAID) of the coxib group. It possesses anti-hyperalgesic, anti-inflammatory and anti-pyretic properties. Robenacoxib inhibits the cyclooxygenase (COX)-2 isoform of COX select... Read More about Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib.

First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats (2022)
Journal Article
Jepson, R. E., Warren, H., Syme, H. M., Elliott, J., & Munroe, P. B. (2022). First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats. Scientific Reports, https://doi.org/10.1038/s41598-022-05494-3

Hypertension (HTN) and chronic kidney disease (CKD) are common in ageing cats. In humans, blood pressure (BP) and renal function are complex heritable traits. We performed the first feline Genome-Wide Association Study (GWAS) of quantitative traits s... Read More about First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats.

Risk factors and implications associated with renal mineralization in chronic kidney disease in cats (2022)
Journal Article
Tang, P., Jepson, R., Chang, Y., Geddes, R., Hopkinson, M., & Elliott, J. (2022). Risk factors and implications associated with renal mineralization in chronic kidney disease in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16363

Background
Nephrocalcinosis is a pathological feature of chronic kidney disease (CKD). Its pathophysiological implications for cats with CKD are unexplored.

Objectives
Identify nephrocalcinosis risk factors and evaluate its influence on CKD prog... Read More about Risk factors and implications associated with renal mineralization in chronic kidney disease in cats.

The effect of myxomatous mitral valve disease severity on packed cell volume in dogs (2021)
Journal Article
Wilshaw, J., Stein, M., Lotter, N., Elliott, J., & Boswood, A. (2021). The effect of myxomatous mitral valve disease severity on packed cell volume in dogs. Journal of Small Animal Practice, 62(6), 428-436. https://doi.org/10.1111/jsap.13308

Objectives The aim of this study was to examine whether associations between disease severity and packed cell volume exist in dogs with myxomatous mitral valve disease. Materials and Methods Data were selected from 289 dogs that had been examined at... Read More about The effect of myxomatous mitral valve disease severity on packed cell volume in dogs.

Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease (2021)
Journal Article
Wilshaw, J., Rosenthal, S., Wess, G., Dickson, D., Bevilacqua, L., Dutton, E., Deinert, M., Abrantes, R., Schneider, I., Oyama, M., Gordon, S., Elliott, J., Xia, D., & Boswood, A. (2021). Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease. Journal of Veterinary Internal Medicine, 35(2), 755-770. https://doi.org/10.1111/jvim.16083

Background Treatment is indicated in dogs with preclinical degenerative mitral valve disease (DMVD) and cardiomegaly (stage B2). This is best diagnosed using echocardiography; however, relying upon this limits access to accurate diagnosis. Objectives... Read More about Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease.

The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia (2021)
Journal Article
Rebecca, F., van den Broek, D., Chang, Y., Biourge, V., Elliott, J., & Jepson, R. (2021). The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia. Journal of Veterinary Internal Medicine, 35(2), 997-1007. https://doi.org/10.1111/jvim.16050

Background Hypercalcemia is commonly observed in cats with azotemic chronic kidney disease (CKD). Dietary phosphate restriction is considered standard of care but may contribute to the development of hypercalcemia. The optimal dietary management stra... Read More about The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia.

Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease (2021)
Journal Article
Quimby, J., Erickson, A., Mcleland, S., Cianciolo, R., Maranon, D., Lunn, K., Elliott, J., Lawson, J., Hess, A., Paschall, R., & Bailey, S. (2021). Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease. Veterinary Sciences, 8(12), https://doi.org/10.3390/vetsci8120314

Kidney tissues from cats with naturally occurring chronic kidney disease (CKD) and adult and senior cats without CKD were assessed to determine whether telomere shortening and nitrosative stress are associated with senescence in feline CKD. The histo... Read More about Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease.

Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios (2021)
Journal Article
Schauf, S., Coltherd, J., Atwal, J., Gilham, M., Carvell-Miller, L., Renfrew, H., Elliott, J., Elliott, D., Bijsmans, E., Biourge, V., Watson, P., & Bakke, A. (2021). Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16263

Background Dietary protein and phosphorus (P) restriction is the mainstay for nutritional management of chronic kidney disease (CKD). However, adequate restriction levels for cats with early CKD remain unclear. Objectives To investigate responses in... Read More about Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios.

Predictors of laminitis development in a cohort of non-laminitic ponies (2021)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.31_13492

Background: Quantifying the risk of laminitis development requires improvement.
Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic pon... Read More about Predictors of laminitis development in a cohort of non-laminitic ponies.

The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome (2021)
Journal Article
Foth, S., Meller, S., Kenward, H., Elliott, J., Pelligand, L., & Volk, H. (2021). The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome. BMC Veterinary Research, 17(1), https://doi.org/10.1186/s12917-021-02931-9

Background Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5-HT3 receptor antagonists to reduce nausea has been described for chemothe... Read More about The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome.

Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure (2021)
Journal Article
Enache, A., Dietrich, U., Drury, O., Trucco, E., MacGillivray, T., Syme, H., Elliott, J., & Chang, Y.-M. (2021). Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure. Journal of Feline Medicine and Surgery,

Objectives Early diagnosis of arterial hypertension is essential to prevent target organ damage. In humans, retinal arteriolar narrowing predicts hypertension. This blinded prospective observational study investigated the retinal vessel diameters amo... Read More about Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure.