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Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus (2020)
Journal Article
Faulkner, A., Tamiato, A., Cathery, W., Rampin, A., Caravaggi, C. M., Jover, E., …Madeddu, P. (2020). Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia, 63(10), 2205-2217

Aims/hypothesis Treatment of vascular complications of diabetes remains inadequate. We reported that muscle pericytes (MPs) from limb muscles of vascular patients with diabetes mellitus display elevated levels of oxidative stress causing a dysfunctio... Read More about Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus.

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells (2020)
Journal Article
Shah, M., Maroof, A., Gikas, P., Mittal, G., Keen, R., Baeten, D., …Roberts, S. J. (2020). Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells. RMD Open, 6(2), e001306. https://doi.org/10.1136/rmdopen-2020-001306

Objectives Interleukin (IL)-17 signalling has been shown to be a key regulator of disease in ankylosing spondylitis (AS) with several IL-17 blockers currently clinically approved. Despite this, the role of IL-17 in bone pathology is poorly understo... Read More about Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells.

Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors (2020)
Journal Article
Bingor, A., Haham, T., Thornton, C., Stern-Bach, Y., & Yaka, R. (2020). Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors. Nature Communications, 11(1), https://doi.org/10.1038/s41467-020-17484-y

Zeta inhibitory peptide (ZIP), a PKMζ inhibitor, is widely used to interfere with the main- tenance of acquired memories. ZIP is able to erase memory even in the absence of PKMζ, via an unknown mechanism. We found that ZIP induces redistribution of t... Read More about Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors.

Emerging Roles for Neuropilin-2 in Cardiovascular Disease (2020)
Journal Article
Harman, J. L., Sayers, J., Chapman, C., & Pellet-Many, C. (2020). Emerging Roles for Neuropilin-2 in Cardiovascular Disease. International Journal of Molecular Sciences, 21(14), 5154. https://doi.org/10.3390/ijms21145154

Cardiovascular disease, the leading cause of death worldwide, is predominantly associated with atherosclerosis. Atherosclerosis is a chronic inflammatory disease characterised by the narrowing of large to medium-sized arteries due to a build-up of pl... Read More about Emerging Roles for Neuropilin-2 in Cardiovascular Disease.

Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus (2020)
Journal Article
Scudder, C. J., Hazuchova, K., Gostelow, R., Church, D. B., Forcada, Y., Fowkes, R. C., & Niessen, S. J. M. (2020). Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus. Journal of Feline Medicine and Surgery, 1098612X2093321. https://doi.org/10.1177/1098612X20933213

Abstract Objectives An affordable and effective treatment is needed to manage feline hypersomatotropism. The aim of this study was to assess whether treatment with oral cabergoline for 90 days in cats with hypersomatotropism and diabetes mellitus i... Read More about Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus.

Microporous Biodegradable Films Promote Therapeutic Angiogenesis (2020)
Journal Article
Hendow, E., Moazen, M., Iacoviello, F., Bozec, L., Pellet‐Many, C., & Day, R. (2020). Microporous Biodegradable Films Promote Therapeutic Angiogenesis. Advanced Healthcare Materials, 2000806

Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amput... Read More about Microporous Biodegradable Films Promote Therapeutic Angiogenesis.

Bimodal Whole-Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed Tomography (2020)
Journal Article
Marr, N., Hopkinson, M., Hibbert, A., Pitsillides, A., & Thorpe, C. (2020). Bimodal Whole-Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed Tomography. Biological Procedures Online, https://doi.org/10.1186/s12575-020-00126-4

BACKGROUND:3-dimensional imaging modalities for optically dense connective tissues such as tendons are limited and typically have a single imaging methodological endpoint. Here, we have developed a bimodal procedure utilising fluorescence-based confo... Read More about Bimodal Whole-Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed Tomography.

β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression (2020)
Journal Article
Tajadura, V., Hansen, M. H., Smith, J., Charles, H., Rickman, M., Farrell-Dillon, K., …Ferro, A. (2020). β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression. Cell Death and Disease, 11(6), https://doi.org/10.1038/s41419-020-2687-6

Increased endothelial cell (EC) apoptosis is associated with the development of atherosclerotic plaques that develop predominantly at sites exposed to disturbed flow (DF). Strategies to promote EC survival may therefore represent a novel therapeutic a... Read More about β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression.

Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities (2020)
Journal Article
D'Anselme, O., Pelligand, L., Veres-Nyeki, K. O., Zaccagnini, A., & Zilberstein, L. (2020). Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities. Veterinary Anaesthesia and Analgesia,

Objectives: There are no standardized methods for teaching anaesthesia in veterinary universities. Our aims were 1) design a holistic audit tool to assess anaesthesia teaching strategies in veterinary universities; 2) to apply the tool to 4 veterina... Read More about Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities.

The chemokine CXCL16 can rescue the defects in insulin signaling and sensitivity caused by palmitate in C2C12 myotubes (2020)
Journal Article
Bitsi, S. (2020). The chemokine CXCL16 can rescue the defects in insulin signaling and sensitivity caused by palmitate in C2C12 myotubes. Cytokine, 133, 155154. https://doi.org/10.1016/j.cyto.2020.155154

In obesity, macrophages infiltrate peripheral tissues and secrete pro-inflammatory cytokines that impact local insulin sensitivity. Lipopolysaccharide (LPS) and the saturated fatty acid (FA) palmitate polarise macrophages towards a pro-inflammatory p... Read More about The chemokine CXCL16 can rescue the defects in insulin signaling and sensitivity caused by palmitate in C2C12 myotubes.

Mapping human serum–induced gene networks as a basis for the creation of biomimetic periosteum for bone repair (2020)
Journal Article
Al Hosni, R., Shah, M., Cheema, U., Roberts, H., Luyten, F., & Roberts, S. (2020). Mapping human serum–induced gene networks as a basis for the creation of biomimetic periosteum for bone repair. Cytotherapy,

The periosteum is a highly vascularised, collagen-rich tissue that plays a crucial role in directing bone repair. This is orchestrated primarily by its resident progenitor cell population. Indeed, preservation of periosteum integrity is critical for... Read More about Mapping human serum–induced gene networks as a basis for the creation of biomimetic periosteum for bone repair.

The Possibility of Zero Limb-Work Gaits in Sprawled and Parasagittal Quadrupeds: Insights from Linkages of the Industrial Revolution (2020)
Journal Article
Usherwood, J. R. (2020). The Possibility of Zero Limb-Work Gaits in Sprawled and Parasagittal Quadrupeds: Insights from Linkages of the Industrial Revolution. Integrative Organismal Biology, 2(1),

Animal legs are diverse, complex, and perform many roles. One defining requirement of legs is to facilitate terrestrial travel with some degree of economy. This could, theoretically, be achieved without loss of mechanical energy if the body could tak... Read More about The Possibility of Zero Limb-Work Gaits in Sprawled and Parasagittal Quadrupeds: Insights from Linkages of the Industrial Revolution.

Patterns of Limb and Epaxial Muscle Activity During Walking in the Fire Salamander, Salamandra salamandra (2020)
Journal Article
Pierce, S. E., Lamas, L. P., Pelligand, L., Schilling, N., & Hutchinson, J. R. (2020). Patterns of Limb and Epaxial Muscle Activity During Walking in the Fire Salamander, Salamandra salamandra. Integrative Organismal Biology, 2(1), https://doi.org/10.1093/iob/obaa015

Synopsis Salamanders and newts (urodeles) are often used as a model system to elucidate the evolution of tetrapod locomotion. Studies range from detailed descriptions of musculoskeletal anatomy and segment kinematics, to bone loading mechanics and in... Read More about Patterns of Limb and Epaxial Muscle Activity During Walking in the Fire Salamander, Salamandra salamandra.

More than one way to be a giant: Convergence and disparity in the hip joints of saurischian dinosaurs (2020)
Journal Article
Tsai, H. P., Middleton, K. M., Hutchinson, J. R., & Holliday, C. M. (2020). More than one way to be a giant: Convergence and disparity in the hip joints of saurischian dinosaurs. Evolution, https://doi.org/10.1111/evo.14017

ABSTRACT Saurischian dinosaurs evolved seven orders of magnitude in body mass, as well as a wide diversity of hip joint morphology and locomotor postures. The very largest saurischians possess incongruent bony hip joints, suggesting that large volum... Read More about More than one way to be a giant: Convergence and disparity in the hip joints of saurischian dinosaurs.

Heterogeneity of proteome dynamics between connective tissue phases of adult tendon (2020)
Journal Article
Choi, H., Simpson, D., Wang, D., Prescott, M., Pitsillides, A. A., Dudhia, J., …Thorpe, C. T. (2020). Heterogeneity of proteome dynamics between connective tissue phases of adult tendon. eLife, 9, https://doi.org/10.7554/elife.55262

Maintenance of connective tissue integrity is fundamental to sustain function, requiring protein turnover to repair damaged tissue. However, connective tissue proteome dynamics remain largely undefined, as do differences in turnover rates of individu... Read More about Heterogeneity of proteome dynamics between connective tissue phases of adult tendon.

Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A (2020)
Journal Article
Faulkner, A., Lynam, E., Purcell, R., Jones, C., Lopez, C., Board, M., …Wheeler-Jones, C. (2020). Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-63900-0

Peroxisome proliferator activated receptor β/δ (PPARβ/δ) has pro-angiogenic functions, but whether PPARβ/δ modulates endothelial cell metabolism to support the dynamic phenotype remains to be established. This study characterised the metabolic respon... Read More about Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A.

Aerodynamic imaging by mosquitoes inspires a surface detector for autonomous flying vehicles (2020)
Journal Article
Nakata, T., Phillips, N., Simões, P., Russell, I. J., Cheney, J. A., Walker, S. M., & Bomphrey, R. J. (2020). Aerodynamic imaging by mosquitoes inspires a surface detector for autonomous flying vehicles. Science, 368(6491), 634-637. https://doi.org/10.1126/science.aaz9634

Some flying animals use active sense to perceive and avoid obstacles. Nocturnal mosquitoes exhibit a behavioral response to divert away from surfaces when vision is unavailable, indicating a short-range, mechanosensory collision avoidance mechanism.... Read More about Aerodynamic imaging by mosquitoes inspires a surface detector for autonomous flying vehicles.

Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy (2020)
Journal Article
Poupon-Bejuit, L., Rocha-Ferreira, E., Thornton, C., Hagberg, H., & Rahim, A. A. (2020). Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy. Frontiers in Cellular Neuroscience, 14, https://doi.org/10.3389/fncel.2020.00112

The perinatal period represents a time of great vulnerability for the developing brain. A variety of injuries can result in death or devastating injury causing profound neurocognitive deficits. Hypoxic-ischemic neonatal encephalopathy (HIE) remains t... Read More about Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy.