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LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis (2024)
Journal Article
Holmes, G., Ferguson, S., Lewis, P., & Echeverri, K. (2024). LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis. Neural Development, 19(1), https://doi.org/10.1186/s13064-024-00193-3

Background The starlet sea anemone, Nematostella vectensis, is an emerging model organism with a high regenerative capacity, which was recently found to possess an orthologue to the human Leucine Rich Repeat Kinase 2 (LRRK2) gene. Mutations in this g... Read More about LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis.

The functions of leg muscles, structures and mechanisms in running (2024)
Journal Article
Usherwood, J. (2024). The functions of leg muscles, structures and mechanisms in running. Biology Letters, 20(8), https://doi.org/10.1098/rsbl.2024.0260

The actions of the major human leg muscles are well established; however, the functions of these muscle actions during steady running remain unclear. Here, leg structures and mechanisms are considered in terms of their functions in meeting the task o... Read More about The functions of leg muscles, structures and mechanisms in running.

Surgical treatment and outcome of primary rib tumours in cats: eight cases (2016-2023) (2024)
Journal Article
Cinti, F., Martano, M., Rossanese, M., Selmic, L., Fontes, G., Cino, M., …Tremolada, G. (2024). Surgical treatment and outcome of primary rib tumours in cats: eight cases (2016-2023). Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13770

ObjectivesTo describe the clinical features and oncologic outcome for cats with primary rib tumours.Materials and MethodsMedical records for cats with surgically treated primary rib tumours from six veterinary referral centres were reviewed. Signalme... Read More about Surgical treatment and outcome of primary rib tumours in cats: eight cases (2016-2023).

Anatomical classification of canine congenital extrahepatic portosystemic shunts based on CT angiography: A SVSTS and VIRIES multi-institutional study in 1082 dogs (2024)
Journal Article
Weisse, C., Fox-Alvarez, W., Grosso, F., Asano, K., Ishigaki, K., Zwingenberger, A., Carroll, K., Scharf, V., Lipscomb, V., Wallace, M., Aly, A., Biscoe, B., Davidson, J., Arai, S., Amato, N., Ryan, S., Woods, S., & An, A. (2024). Anatomical classification of canine congenital extrahepatic portosystemic shunts based on CT angiography: A SVSTS and VIRIES multi-institutional study in 1082 dogs. Veterinary Radiology and Ultrasound, https://doi.org/10.1111/vru.13415

Canine congenital extrahepatic portosystemic shunt (EHPSS) morphologies have not been fully elucidated. The goal of this retrospective, multi-institutional study was to use CT angiography to create an anatomical-based nomenclature system for canine c... Read More about Anatomical classification of canine congenital extrahepatic portosystemic shunts based on CT angiography: A SVSTS and VIRIES multi-institutional study in 1082 dogs.

Impact of Lameness on Brush Use in a Loose-Housed Dairy System (2024)
Journal Article
Burton, Y. I., & Blackie, N. (2024). Impact of Lameness on Brush Use in a Loose-Housed Dairy System. Ruminants, 4(3), 375-386. https://doi.org/10.3390/ruminants4030027

This study focused on a group of 49 high-yielding dairy cows (primarily Holstein Friesians) and how their interactions with wall-mounted automated brushes correlated to their mobility (also described as lameness) score (AHDB 0–3 system. Of the 49 ani... Read More about Impact of Lameness on Brush Use in a Loose-Housed Dairy System.

EfpA is required for re-growth of Mycobacterium tuberculosis following isoniazid exposure (2024)
Journal Article
Roberts, A. H., Moon, C. W., Faulkner, V., Kendall, S. L., Waddell, S., & Bacon, J. (in press). EfpA is required for re-growth of Mycobacterium tuberculosis following isoniazid exposure. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/aac.00261-24

Efflux of antibiotics is a survival strategy in bacteria. Mycobacterium tuberculosis has approximately sixty efflux pumps, but little is known about the role of each pump, or which moieties that they efflux. The putative efflux pump, EfpA, is a membe... Read More about EfpA is required for re-growth of Mycobacterium tuberculosis following isoniazid exposure.

A standardised approach to quantifying activity in domestic dogs (2024)
Journal Article
Karimjee, K., Harron, R., Piercy, R., & Daley, M. (2024). A standardised approach to quantifying activity in domestic dogs. Royal Society Open Science, 11(7), https://doi.org/10.1098/rsos.240119

Objective assessment of activity via accelerometry can provide valuable insights into dog health and welfare. Common activity metrics involve using acceleration cut-points to group data into intensity categories and reporting the time spent in each c... Read More about A standardised approach to quantifying activity in domestic dogs.

A novel method to measure the impact of water quality on judgement bias in wild juvenile fish   (2024)
Journal Article
Freire, R., & Nicol, C. (in press). A novel method to measure the impact of water quality on judgement bias in wild juvenile fish  . Global Ecology and Conservation, https://doi.org/10.1016/j.gecco.2024.e03086

Methods to examine judgement bias in free-living animals in situ are required to address ecological, conservation and animal welfare questions. Following on from recent research showing judgement bias in fish, we developed a novel approach to measure... Read More about A novel method to measure the impact of water quality on judgement bias in wild juvenile fish  .

Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases? (2024)
Journal Article
Elliott, J., & Oyama, M. A. (2024). Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases?. Journal of Veterinary Pharmacology and Therapeutics, n/a(n/a), https://doi.org/10.1111/jvp.13472

Abstract Sodium glucose transporter type 2 (SGLT2) inhibitors have been introduced into human medicine where their beneficial effects go beyond the expected improvement in blood glucose control. These drugs appear to prevent progression of both cardi... Read More about Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases?.

Comparable foraging effort and habitat use between two geographically proximate tropical seabird colonies (2024)
Journal Article
Trevail, A., Vallocchia, S., Nicoll, M., Carr, P., Votier, S., Wood, H., & Freeman, R. (2024). Comparable foraging effort and habitat use between two geographically proximate tropical seabird colonies. Marine Biology, 171(8), https://doi.org/10.1007/s00227-024-04464-9

Effective seabird conservation requires understanding their marine spatial ecology. Tracking can reveal details of their foraging ecology and habitat use, as well as the suitability of marine protected areas for at-sea conservation, but results are o... Read More about Comparable foraging effort and habitat use between two geographically proximate tropical seabird colonies.

Conformation-associated health in pet rabbits in the UK: A VetCompass cohort study (2024)
Journal Article
O'Neill, D., Williams, A., Brodbelt, D. C., Church, D. B., & Hedley, J. (2024). Conformation-associated health in pet rabbits in the UK: A VetCompass cohort study. Herpetological Conservation and Biology, https://doi.org/10.1002/vetr.4396

Abstract Background Domestic rabbit breeds vary substantially from the wild rabbit body type. However, little is known about how the conformation of pet rabbits influences their health. Methods Data were extracted from VetCompass anonymised clinical... Read More about Conformation-associated health in pet rabbits in the UK: A VetCompass cohort study.

Characterisation of phenotypic patterns in equine exercise-associated myopathies (2024)
Journal Article
Lindsay-McGee, V., Massey, C., Li, Y., Clark, E., Psifidi, A., & Piercy, R. (2024). Characterisation of phenotypic patterns in equine exercise-associated myopathies. Equine Veterinary Journal, https://doi.org/10.1111/evj.14128

Background Equine exercise-associated myopathies are prevalent, clinically heterogeneous, generally idiopathic disorders characterised by episodes of myofibre damage that occur in association with exercise. Episodes are intermittent and vary within a... Read More about Characterisation of phenotypic patterns in equine exercise-associated myopathies.

Survey assessing foot trimmer involvement in managing lameness in UK beef cattle (2024)
Journal Article
Fitzsimmonds, H., Fishwick, J., & Mahendran, S. (2024). Survey assessing foot trimmer involvement in managing lameness in UK beef cattle. Veterinary Record, https://doi.org/10.1002/vetr.4151

Background: Cattle lameness is a significant welfare and economic problem facing the livestock industry. Published research has investigated foot trimming practices in dairy herds, but little is known about the practices in beef herds. Therefore, the... Read More about Survey assessing foot trimmer involvement in managing lameness in UK beef cattle.

Later-age neutering causes lower risk of early‐onset urinary incontinence than early neutering–a VetCompass target trial emulation study (2024)
Journal Article
O'Neill, D., Diaz-Ordaz, K., Pegram, C., Brodbelt, D. C., Chang, Y., Hall, J. L., & Church, D. B. (2024). Later-age neutering causes lower risk of early‐onset urinary incontinence than early neutering–a VetCompass target trial emulation study. Herpetological Conservation and Biology, 19(7), e0305526. https://doi.org/10.1371/journal.pone.0305526

There is growing evidence supporting clinically important associations between age at neutering in bitches and subsequent urinary incontinence (UI), although much of this evidence to date is considered weak. Target trial emulation is an innovative ap... Read More about Later-age neutering causes lower risk of early‐onset urinary incontinence than early neutering–a VetCompass target trial emulation study.

Cardiotrophin-1 therapy reduces disease severity in a murine model of glomerular disease (2024)
Journal Article
Perretta-Tejedor, N., Price, K. L., Pomeranz, G., Kolatsi-Joannou, M., Jafree, D. J., Martínez-Salgado, C., …Vasilopoulou, E. (2024). Cardiotrophin-1 therapy reduces disease severity in a murine model of glomerular disease. Physiological Reports, 12(13), https://doi.org/10.14814/phy2.16129

Cardiotrophin-1 (CT-1), a member of the interleukin (IL)-6 cytokine family, has renoprotective effects in mouse models of acute kidney disease and tubulointerstitial fibrosis, but its role in glomerular disease is unknown. To address this, we used th... Read More about Cardiotrophin-1 therapy reduces disease severity in a murine model of glomerular disease.