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<i>Plasmodium</i> LCCL domain-containing modular proteins have their origins in the ancestral alveolate (2024)
Journal Article
De Hoest-Thompson, C., Marugan-Hernandez, V., & Dessens, J. (2024). Plasmodium LCCL domain-containing modular proteins have their origins in the ancestral alveolate. Open Biology, 14(6), https://doi.org/10.1098/rsob.230451

Plasmodium species encode a unique set of six modular proteins named LCCL lectin domain adhesive-like proteins (LAPs) that operate as a complex and that are essential for malaria parasite transmission from mosquito to vertebrate. LAPs possess complex... Read More about <i>Plasmodium</i> LCCL domain-containing modular proteins have their origins in the ancestral alveolate.

Determinants of Thoroughbred yearling sales price in the UK (2024)
Journal Article
Mouncey, R. R., Alarcon, P., & Verheyen, K. L. (2024). Determinants of Thoroughbred yearling sales price in the UK. Veterinary Record Open, 11(1), https://doi.org/10.1002/vro2.81

Background Industry-level figures suggest that up to two-thirds of Thoroughbred breeding operations in the UK are unprofitable and that around half of sales transactions of Thoroughbred yearlings, commercial breeders’ predominant income source, retu... Read More about Determinants of Thoroughbred yearling sales price in the UK.

Regenerative Medicine and Biological Treatments (2024)
Book Chapter
Guest, D., Schramme, M., & Smith, R. (2024). Regenerative Medicine and Biological Treatments. In Essential Facts of Equine Physical Therapy, Rehabilitation and Sports Medicine

Many tissues undergo poor natural regeneration following injury or disease and the reparative healing process can lead to tissues that are functionally inferior and prone to re-injury. Regenerative medicine aims to induce natural tissue regeneration... Read More about Regenerative Medicine and Biological Treatments.

Variations in touch representation in the hummingbird and zebra finch forebrain (2024)
Journal Article
Gaede, A., Wu, P., & Leitch, D. (2024). Variations in touch representation in the hummingbird and zebra finch forebrain. Current Biology, 34(12), https://doi.org/10.1016/j.cub.2024.04.081

Somatosensation is essential for animals to perceive the external world through touch, allowing them to detect physical contact, temperature, pain, and body position. Studies on rodent vibrissae have highlighted the organization and processing in mam... Read More about Variations in touch representation in the hummingbird and zebra finch forebrain.

Is badger culling associated with risk compensation behaviour among cattle farmers? (2024)
Journal Article
Brunton, L., & Enticott, G. (in press). Is badger culling associated with risk compensation behaviour among cattle farmers?. Veterinary Record, https://doi.org/10.1002/vetr.4152

Background Risk compensation theory suggests that behaviours are modified in response to interventions that remove risks by substituting them with other risky behaviours to maintain a ‘risk equilibrium’. Alternatively, risk reduction interventions m... Read More about Is badger culling associated with risk compensation behaviour among cattle farmers?.

Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response (2024)
Journal Article
Morris, R. H., Counsell, S. J., McGonnell, I. M., & Thornton, C. (in press). Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response. Journal of Physiology, https://doi.org/10.1113/jp285978

World Health Organisation data suggest that up to 99% of the global population are exposed to air pollutants above recommended levels. Impacts to health range from increased risk of stroke and cardiovascular disease to chronic respiratory conditions,... Read More about Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response.

Re-evaluating the placebo response in recent canine dietary epilepsy trials (2024)
Journal Article
Schmidt, T., Meyerhoff, N., Meller, S., Twele, F., Charalambous, M., Berk, B., …Volk, H. (2024). Re-evaluating the placebo response in recent canine dietary epilepsy trials. BMC Veterinary Research, 20(1), https://doi.org/10.1186/s12917-024-04066-z

The placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can significantly influence the efficacy evaluation of new treatments. It was hypothesised that the placebo respo... Read More about Re-evaluating the placebo response in recent canine dietary epilepsy trials.

Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022 (2024)
Journal Article
Beard, S., Hall, E. J., Bradbury, J., Carter, A. J., Gilbert, S., & O'Neill, D. G. (2024). Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022. Herpetological Conservation and Biology, https://doi.org/10.1002/vetr.4153

Background: Dogs are exposed to increasing environmental risk for developing heat-related illness (HRI), with 2022 recorded as the hottest year to date in the UK and most of Europe. Methods: This study used VetCompass data to report the incidence ris... Read More about Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022.

Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022 (2024)
Journal Article
O'Neill, D., Skipper, A. M., & Packer, R. M. . A. (2024). Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022. Herpetological Conservation and Biology, 19(5), e0303498. https://doi.org/10.1371/journal.pone.0303498

Background Research into canine health and welfare is supported by Government, charitable and private UK funding organisations. However, there is no current overall visibility or coordination of these funding activities, potentially compromising opti... Read More about Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022.

Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy (2024)
Journal Article
Poupon-Bejuit, L., Geard, A., Millicheap, N., Rocha-Ferreira, E., Hagberg, H., Thornton, C., & Rahim, A. A. (2024). Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy. EMBO Molecular Medicine, https://doi.org/10.1038/s44321-024-00079-1

Hypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to the neonatal brain during labor, leading to infant mortality or severe brain damage, with a global incidence of 1.5 per 1000 live births. Glucagon-like Peptide 1 R... Read More about Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy.

Environmental Land Management scheme (ELMs) (2024)
Report
Myers, J., Whatford, L., Qi, A., Cooke, R., Payne-Gifford, S., Tak, M., …Haesler, B. (2024). Environmental Land Management scheme (ELMs). not applicable

An unprecedented set of challenges now confronts livestock food systems in Britain. With household budgets being squeezed, producers, processors, retailers and wholesalers are under increasing pressure to maintain the affordability of their products... Read More about Environmental Land Management scheme (ELMs).

Animal Health and Welfare Pathway (AHWP) (2024)
Report
Payne-Gifford, S., Myers, J., Whatford, L., Tak, M., van Winden, S., Qi, A., …Barling, D. (2024). Animal Health and Welfare Pathway (AHWP). RVC Research online: not applicable

An unprecedented set of challenges now confronts livestock food systems in Britain. With household budgets being squeezed, producers, processors, retailers and wholesalers are under increasing pressure to maintain the affordability of their products... Read More about Animal Health and Welfare Pathway (AHWP).

Transparency in the beef and sheep meat food systems enables agency and fairness. (2024)
Report
Whatford, L., Payne-Gifford, S., Myers, J., Tak, M., van Winden, S., Qi, A., …Haesler, B. (2024). Transparency in the beef and sheep meat food systems enables agency and fairness. RVC Research online: not applicable

An unprecedented set of challenges now confronts livestock food systems in Britain. With household budgets being squeezed, producers, processors, retailers and wholesalers are under increasing pressure to maintain the affordability of their products... Read More about Transparency in the beef and sheep meat food systems enables agency and fairness..

Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion. (2024)
Journal Article
Beeston, D., Szladovits, B., & Cortellini, S. (in press). Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion. Journal of the American Veterinary Medical Association, https://doi.org/10.2460/javma.24.03.0148

Abstract Objective To describe the presentation, diagnosis and treatment of four cases of splenic torsion with associated spherocytosis. Animals Four client-owned dogs with spherocytosis and splenic torsion. Case Presentation Each dog prese... Read More about Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion..

Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy (2024)
Journal Article
Goldberg, A., Masci, L., O'Donnell, P., Green, R., Brooking, D., Bassett, P., …Smith, R. (2024). Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy. Scientific Reports, 14(1), https://doi.org/10.1038/s41598-024-61399-3

Achilles tendinopathy is a disabling condition that affects more than 50% of runners. Pre-clinical studies in a large animal model of naturally-occurring tendinopathy similar to human Achilles tendinopathy has shown benefits of autologous bone marrow... Read More about Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy.

A screen for <i>Plasmodium falciparum</i> sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions (2024)
Journal Article
Segireddy, R., Belda, H., Yang, A., Dundas, K., Knoeckel, J., Galaway, F., …Douglas, A. (2024). A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions. Malaria Journal, 23(1), https://doi.org/10.1186/s12936-024-04913-2

Background Sporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to merozoite invasion of erythrocytes. In the case of the Plasmodium blood-stage, efforts to identify host-pa... Read More about A screen for <i>Plasmodium falciparum</i> sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions.

ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats (2024)
Journal Article
LeVine, D., Kidd, L., Garden, O., Brooks, M., Goggs, R., Kohn, B., …Spada, E. (2024). ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16996

Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. Immune thrombocytopenia less commonly affects cats but is an important cause of mortality and treatment-associated morbidity in both species. Immune thromb... Read More about ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats.

A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease (2024)
Journal Article
Jiang, J., Hiron, T. K., Agbaedeng, T., Malhotra, Y., Drydale, E., Bancroft, J., …O’Callaghan, C. A. (2024). A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease. Circulation Research, 135(1), 6-25. https://doi.org/10.1161/circresaha.123.324172

BACKGROUND: Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. Although over 250 genetic risk loci have been identified through genome-wide association studies, the specifi... Read More about A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.

Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity (2024)
Journal Article
Then, C., Paillas, S., Moomin, A., Misheva, M., Moir, R., Hay, S., …Kiltie, A. (2024). Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity. Microbiome, 12(1), https://doi.org/10.1186/s40168-024-01804-1

Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota... Read More about Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.