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All Outputs (171)

Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK (2023)
Journal Article
Pegram, C., Brodbelt, D., Diaz-Ordaz, K., Chang, Y.-M., Frykfors von Hekkel, A., Church, D., & O'Neill, D. (2023). Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2023.105952

This study aimed to evaluate demographic risk factors associated with unilateral cranial cruciate ligament (CCL) rupture diagnosis and to explore demographic and clinical risk factors associated with management of unilateral CCL rupture in dogs under... Read More about Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK.

Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review (2023)
Journal Article
Seligman, C., Chang, Y., Luo, J., & Garden, O. (2023). Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review. Frontiers in Neurology, 13, https://doi.org/10.3389/fneur.2022.1004810

Background While immune checkpoint inhibitors (ICIs) have been revolutionary in the treatment of cancer, their administration has been associated with a variety of immune-related adverse events (irAEs), including myasthenia gravis (MG), and Lambert-E... Read More about Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review.

Predictors of laminitis development in a cohort of nonlaminitic ponies (2023)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, Y., & Menzies-Gow, N. (2023). Predictors of laminitis development in a cohort of nonlaminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13572

Background Quantifying risk factors for laminitis development requires improvement. Objectives To identify the most useful physical examination, metabolic and management factors to predict laminitis development in client-owned, nonlaminitic ponies. S... Read More about Predictors of laminitis development in a cohort of nonlaminitic ponies.

Economic evaluation of antimicrobial usage surveillance in livestock: -EN- Economic evaluation of antimicrobial usage surveillance in livestock -FR- Évaluation économique de la surveillance exercée sur l'utilisation d'agents antimicrobiens chez les animaux d'élevage -ES- Evaluación en clave económica de la vigilancia del uso de agentes antimicrobianos en el ganado (2023)
Journal Article
ALARCON, P., STRANG, C., CHANG, Y., & TAK, M. (2023). Economic evaluation of antimicrobial usage surveillance in livestock: -EN- Economic evaluation of antimicrobial usage surveillance in livestock -FR- Évaluation économique de la surveillance exercée sur l'utilisation d'agents antimicrobiens chez les animaux d'élevage -ES- Evaluación en clave económica de la vigilancia del uso de agentes antimicrobianos en el ganado. Scientific and Technical Review, 42, 42-51. https://doi.org/10.20506/rst.42.3347

Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma (2022)
Journal Article
Azzariti, S., Bond, R., Loeffler, A., Zendri, F., Timofte, D., Chang, Y.-M., & Pelligand, L. (2022). Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma. Antibiotics, https://doi.org/10.3390/antibiotics11091204

Fluoroquinolones (FQ) are commonly used in dogs with bacterial skin infections. Their use as first choice, along with the increased incidence of FQ-resistance, represents a risk to animal and public health. Our study determined minimum inhibitory (M... Read More about Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018) (2022)
Journal Article
van den Broek, D., Geddes, R., Lotter, N., Chang, Y., Elliott, J., & Jepson, R. (2022). Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16430

Background Hypercalcemia is associated with chronic kidney disease (CKD) in cats, but studies assessing the physiologically relevant ionized calcium fraction are lacking. Objectives To describe the prevalence and incidence rate of ionized hypercalcem... Read More about Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018).

The importance of fine-scale predictors of wild boar habitat use in an isolated population (2022)
Journal Article
Bacigalupo, S. A., Chang, Y.-M., Dixon, L. K., Gubbins, S., Kucharski, A. J., & Drewe, J. A. (2022). The importance of fine-scale predictors of wild boar habitat use in an isolated population. Ecology and Evolution, 12, -. https://doi.org/10.1002/ece3.9031

1. Predicting the likelihood of wildlife presence at potential wildlife-livestock interfaces is challenging. These interfaces are usually relatively small geographical areas where landscapes show large variation over small distances. Models of wildli... Read More about The importance of fine-scale predictors of wild boar habitat use in an isolated population.

The importance of fine-scale predictors of wild boar presence in an isolated population (2022)
Journal Article
Bacigalupo, S. A., Chang, Y.-M., Dixon, L. K., Gubbins, S., Kucharski, A. J., & Drewe, J. A. (2022). The importance of fine-scale predictors of wild boar presence in an isolated population. Methods in Ecology and Evolution, https://doi.org/10.1002/ece3.9031

1. Predicting the likelihood of wildlife presence at potential wildlife-livestock interfaces is challenging. These interfaces are usually relatively small geographical areas where landscapes show large variation over small distances. Models of wildli... Read More about The importance of fine-scale predictors of wild boar presence in an isolated population.

Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure (2022)
Journal Article
Wilshaw, J., Boswood, A., Chang, Y., Sands, C., Camuzeaux, S., Lewis, M., Xia, D., & Connolly, D. (2022). Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure. Metabolomics, 18(6), https://doi.org/10.1007/s11306-022-01887-7

Introduction Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metaboli... Read More about Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure.

Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints (2022)
Journal Article
Ajami, S., Javaheri, B., Chang, Y., Maruthainar, N., Khan, T., Donaldson, J., Pitsillides, A., & Liu, C. (2022). Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints. Scientific Reports, 12(1), https://doi.org/10.1038/s41598-022-10600-6

Early diagnosis of osteoarthritis (OA), before the onset of irreversible changes is crucial for understanding the disease process and identifying potential disease-modifying treatments from the earliest stage. OA is a whole joint disease and affects... Read More about Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints.

Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass (2022)
Journal Article
Starybrat, D., Jepson, R., Bristow, P., Peterson, S., Yerramilli, M., Yerramilli, M., Chang, Y.-M., & Cortellini, S. (online). Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.13250

Objective To assess the occurrence of acute kidney injury (AKI) in dogs undergoing cardiac surgery under cardiopulmonary bypass (CPB) and explore associations between traditional and novel serum and urinary biomarkers. Design Prospective cohort study... Read More about Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass.

Risk factors and implications associated with renal mineralization in chronic kidney disease in cats (2022)
Journal Article
Tang, P., Jepson, R., Chang, Y., Geddes, R., Hopkinson, M., & Elliott, J. (2022). Risk factors and implications associated with renal mineralization in chronic kidney disease in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16363

Background
Nephrocalcinosis is a pathological feature of chronic kidney disease (CKD). Its pathophysiological implications for cats with CKD are unexplored.

Objectives
Identify nephrocalcinosis risk factors and evaluate its influence on CKD prog... Read More about Risk factors and implications associated with renal mineralization in chronic kidney disease in cats.

The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia (2021)
Journal Article
Rebecca, F., van den Broek, D., Chang, Y., Biourge, V., Elliott, J., & Jepson, R. (2021). The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia. Journal of Veterinary Internal Medicine, 35(2), 997-1007. https://doi.org/10.1111/jvim.16050

Background Hypercalcemia is commonly observed in cats with azotemic chronic kidney disease (CKD). Dietary phosphate restriction is considered standard of care but may contribute to the development of hypercalcemia. The optimal dietary management stra... Read More about The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia.

Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy (2021)
Journal Article
Hornby, N., Drees, R., Harron, R., Chang, R., Wells, D., & Piercy, R. (2021). Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy. Neuromuscular Disorders, 31(8), 736-751. https://doi.org/10.1016/j.nmd.2021.05.010

The DE50-MD canine model of Duchenne muscular dystrophy (DMD) has a dystrophin gene splice site mutation causing deletion of exon 50, an out-of-frame transcript and absence of dystrophin expression in striated muscles. We hypothesized that the muscul... Read More about Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy.

Influence of endocrine disease on l-lactate concentrations in blood of ponies (2021)
Journal Article
Dunkel, B., Knowles, E., Chang, Y., & Menzies-Gow, N. (2021). Influence of endocrine disease on l-lactate concentrations in blood of ponies. Journal of Veterinary Internal Medicine, 35(3), 1582-1588. https://doi.org/10.1111/jvim.16079

Background Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l-lactate concentrations are positively correlated with measures of insuli... Read More about Influence of endocrine disease on l-lactate concentrations in blood of ponies.

Treatment failure in hyperthyroid cats after radioiodine (I-131) injection (2021)
Journal Article
Mullowney, D., Chang, Y., Glanemann, B., & Syme, H. (2021). Treatment failure in hyperthyroid cats after radioiodine (I-131) injection. Journal of Veterinary Internal Medicine, 35(4), 1688-1696. https://doi.org/10.1111/jvim.16161

Background There is limited published information on the outcome for cats where total thyroxine concentration (TT4) remains elevated after treatment with radioactive iodine (RAI). Objective To determine the frequency of, and predictors for, subsequen... Read More about Treatment failure in hyperthyroid cats after radioiodine (I-131) injection.

Hypoglycin A absorption in sheep without concurrent clinical or biochemical evidence of disease (2021)
Journal Article
Gonzalez-Medina, S., Bevin, W., Alzola-Domingo, R., Chang, Y., & Piercy, R. (2021). Hypoglycin A absorption in sheep without concurrent clinical or biochemical evidence of disease. Journal of Veterinary Internal Medicine, 35(2), 1170-1176. https://doi.org/10.1111/jvim.16077

Background Hypoglycin A (HGA) intoxication after ingestion of Acer spp. tree material has never been confirmed in domesticated ruminants despite their similar grazing habitats. Objectives To investigate whether sheep have low HGA bioavailability caus... Read More about Hypoglycin A absorption in sheep without concurrent clinical or biochemical evidence of disease.

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy (2021)
Journal Article
Economu, L., Chang, Y., Priestnall, S., & Kathrani, A. (2021). The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy. Journal of Veterinary Internal Medicine, 35(3), 1297-1305. https://doi.org/10.1111/jvim.16125

Background The effect of assisted enteral feeding on treatment outcome in dogs with protein-losing enteropathy (PLE) is unknown. Objectives To determine if dogs with inflammatory PLE that had an enteral feeding tube placed had better outcome vs dogs... Read More about The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy.